D
Dan Mishmar
Researcher at Ben-Gurion University of the Negev
Publications - 77
Citations - 5053
Dan Mishmar is an academic researcher from Ben-Gurion University of the Negev. The author has contributed to research in topics: Mitochondrial DNA & Gene. The author has an hindex of 29, co-authored 71 publications receiving 4535 citations. Previous affiliations of Dan Mishmar include University of California, Irvine & Hebrew University of Jerusalem.
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Journal ArticleDOI
Natural selection shaped regional mtDNA variation in humans
Dan Mishmar,Eduardo Ruiz-Pesini,Pawel Golik,Vincent Macaulay,Andrew G. Clark,S.H. Hosseini,Martin Brandon,Kirk A. Easley,Estella B. Chen,Michael D. Brown,Rem I. Sukernik,Antonel Olckers,Douglas C. Wallace +12 more
TL;DR: It is concluded that selection may have played a role in shaping human regional mtDNA variation and that one of the selective influences was climate.
Journal ArticleDOI
Effects of Purifying and Adaptive Selection on Regional Variation in Human mtDNA
TL;DR: A phylogenetic analysis of 1125 global human mitochondrial DNA sequences permitted positioning of all nucleotide substitutions according to their order of occurrence, and particularly highly conserved amino acid substitutions were found at the roots of multiple mtDNA lineages from higher latitudes.
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An enhanced MITOMAP with a global mtDNA mutational phylogeny.
Eduardo Ruiz-Pesini,Marie T. Lott,Vincent Procaccio,Jason C. Poole,Marty C. Brandon,Dan Mishmar,Dan Mishmar,Christina Yi,James Kreuziger,Pierre Baldi,Douglas C. Wallace +10 more
TL;DR: The MITOMAP data system for the human mitochondrial genome has been greatly enhanced by the addition of a navigable mutational mitochondrial DNA (mtDNA) phylogenetic tree of ∼3000 mtDNA coding region sequences plus expanded pathogenic mutation tables and a nuclear-mtDNA pseudogene (NUMT) data base.
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Mitochondrial bioenergetics as a major motive force of speciation.
TL;DR: Genetic and biochemical evidence is discussed for the possible involvement of this unique system, encoded by two genomes that differ by an order of magnitude in their mutation rates in processes leading to speciation events.
Journal ArticleDOI
Molecular characterization of a common fragile site (FRA7H) on human chromosome 7 by the cloning of a simian virus 40 integration site
Dan Mishmar,Ayelet Rahat,Stephen W. Scherer,Gerald Nyakatura,Bernd Hinzmann,Yoshinori Kohwi,Yael Mandel-Gutfroind,Jeffrey R. Lee,Bernd Drescher,Dean E. Sas,Hanah Margalit,Mattias Platzer,Aryeh Weiss,Lap-Chee Tsui,André Rosenthal,Batsheva Kerem +15 more
TL;DR: These unusual DNA characteristics are possibly intrinsic properties of common fragile sites that may affect their replication and condensation as well as organization, and may lead to fragility.