Dana A P Evans

TL;DR: This work shows in Drosophila that Notch signaling is limited by the activity of two Nedd4 family HECT domain proteins, Suppressor of deltex [Su(dx)] and DNedd4, and proposes a model in which endocytic sorting of Notch mediates a decision between its activation and downregulation.

TL;DR: Overexpression of Su( dx) results in ectopic vein differentiation, wing margin loss, and wing growth phenotypes and enhances the phenotypes of loss-of-function mutations in Notch, evidence that supports the conclusion that Su(dx) has a role in the downregulation of Notch signaling.

TL;DR: Phenotypes were identified for Su(dx) in wing vein development, and a role was demonstrated for the gene between 20 and 30 hr after puparium formation, which corresponds to the period when the Notch protein is involved in refining the vein competent territories.

TL;DR: It is shown that Su(dx) does regulate the level of NotCh signalling in vivo, upstream of Notch target genes and in different developmental contexts, including a previously unknown role in leg joint formation.

TL;DR: It is argued that while efforts develop d1,ea,e-toleran1 brood stock may contribule to re;toration efforts, the roles of demographics and disease status on fecundity of brood ~lock and the role of estuarrne circulation in regions sullable for subsequen1 recrui tment are argued.