Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins.
Marian B. Wilkin,Ann Marie Carbery,Maggy Fostier,Hanna Aslam,Sabine L. Mazaleyrat,Jenny Higgs,Anna Myat,Dana A P Evans,Michael Cornell,Martin Baron +9 more
TLDR
This work shows in Drosophila that Notch signaling is limited by the activity of two Nedd4 family HECT domain proteins, Suppressor of deltex [Su(dx)] and DNedd4, and proposes a model in which endocytic sorting of Notch mediates a decision between its activation and downregulation.About:
This article is published in Current Biology.The article was published on 2004-12-29 and is currently open access. It has received 198 citations till now. The article focuses on the topics: Notch proteins & Notch signaling pathway.read more
Citations
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Journal ArticleDOI
Notch signalling: a simple pathway becomes complex
TL;DR: Although the intracellular transduction of the Notch signal is remarkably simple, with no secondary messengers, this pathway functions in an enormous diversity of developmental processes and its dysfunction is implicated in many cancers.
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Endocytosis and signalling: intertwining molecular networks
TL;DR: The mechanistic and functional principles that underlie the relationship between signalling and endocytosis in cell biology are becoming increasingly evident across many systems.
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Physiological functions of the HECT family of ubiquitin ligases
Daniela Rotin,Sharad Kumar +1 more
TL;DR: The functions of HECT E3 enyzmes in metazoans are now becoming clearer from in vivo studies, and regulate the trafficking of many receptors, channels, transporters and viral proteins.
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Notch Signaling: The Core Pathway and Its Posttranslational Regulation
TL;DR: This review describes the core developmental logic of Notch signaling and how regulatory mechanisms tailor Notch pathway outputs to specific developmental scenarios.
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The Notch signalling system: recent insights into the complexity of a conserved pathway.
TL;DR: This work has revealed an extraordinarily complex network of genes that can affect Notch activity in Drosophila melanogaster and presented an unprecedented insight into the way in which such a fundamental signalling mechanism is controlled by the genome.
References
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Journal ArticleDOI
Notch Signaling: Cell Fate Control and Signal Integration in Development
TL;DR: Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development, providing a general developmental tool to influence organ formation and morphogenesis.
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Analysis of genetic mosaics in developing and adult Drosophila tissues
Tian Xu,Gerald M. Rubin +1 more
TL;DR: This work has constructed a series of strains to facilitate the generation and analysis of clones of genetically distinct cells in developing and adult tissues of Drosophila, providing an unprecedented opportunity to perform systematic genetic screens for mutations affecting many biological processes.
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A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase.
TL;DR: Data strongly suggest that the rat 100-kDa protein and RSP5, as well as the other E6-AP-related proteins, belong to a class of functionally related E3 ubiquitin-protein ligases, defined by a domain homologous to the E 6-AP carboxyl terminus (hect domain).
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Notch Signaling: From the Outside In
Jeff S. Mumm,Raphael Kopan +1 more
TL;DR: The efforts of many roups that, over the past decade, contributed to the discovry that a novel signaling paradigm, Regulated Intramembrane Proteolysis (RIP), controls Notch receptor activation are summarized.
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A ligand-induced extracellular cleavage regulates γ-secretase-like proteolytic activation of Notch1
Jeff S. Mumm,Eric H. Schroeter,Meera T. Saxena,Adam Griesemer,Xiaolin Tian,Duojia Pan,William J. Ray,Raphael Kopan +7 more
TL;DR: It is demonstrated that ligand binding facilitates cleavage at a novel site (S2), within the extracellular juxtamembrane region, which serves to release ectodomain repression of NICD production.
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Notch Signaling: Cell Fate Control and Signal Integration in Development
The Drosophila Tumor Suppressor vps25 Prevents Nonautonomous Overproliferation by Regulating Notch Trafficking
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