Dana C. Danielson

TL;DR: It is shown that under conditions where other copper complexes kill human hepatoma cells, Cu(I)-L-histidine is an effective catalyst for CuAAC labeling of live cells following metabolic incorporation of an alkyne-labeled sugar into glycosylated proteins expressed on the cell surface.

TL;DR: The nonlinear variant of Raman spectroscopy, coherent anti-Stokes Raman scattering (CARS) microscopy, combines powerful Raman signal enhancement with several other advantages such as label-free detection and has been used to image various cellular processes including host-pathogen interactions and lipid metabolism.

TL;DR: Strain-promoted cycloadditions of cyclic nitrones with cyclooctynes proceed with rate constants up to 59 times faster than the analogous reaction of azides, which can be applied for direct labeling of proteins and for live cell imaging of cancer cells.

TL;DR: The p19 protein is expressed by tombusviruses as a suppressor of RNA silencing and functions to sequester small RNA duplexes, thereby preventing induction of the pathway as mentioned in this paper.

TL;DR: The results suggest that p19 can be engineered to enhance its affinity toward specific small RNA molecules, particularly noncanonical miRNAs that are distinguishable based on locations of base-pair mismatches.