J
John Paul Pezacki
Researcher at University of Ottawa
Publications - 165
Citations - 6673
John Paul Pezacki is an academic researcher from University of Ottawa. The author has contributed to research in topics: RNA & RNA silencing. The author has an hindex of 40, co-authored 159 publications receiving 6093 citations. Previous affiliations of John Paul Pezacki include McMaster University & National Institute for Nanotechnology.
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Journal ArticleDOI
Genomic analysis of the host response to hepatitis C virus infection.
Andrew I. Su,John Paul Pezacki,Lisa Wodicka,Amy D. Brideau,Lubica Supekova,Robert Thimme,Stefan Wieland,Jens Bukh,Robert H. Purcell,Peter G. Schultz,Francis V. Chisari +10 more
TL;DR: Gene expression analysis of liver biopsies in acutely infected chimpanzees reveals genome-wide transcriptional changes that reflect the establishment, spread, and control of infection, and they reveal potentially unique antiviral programs associated with clearance of HCV infection.
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Cellular consequences of copper complexes used to catalyze bioorthogonal click reactions.
David C. Kennedy,Craig S. McKay,Craig S. McKay,Marc C.B. Legault,Marc C.B. Legault,Dana C. Danielson,Dana C. Danielson,Jessie A. Blake,Jessie A. Blake,Adrian F. Pegoraro,Albert Stolow,Zoltán Mester,John Paul Pezacki,John Paul Pezacki +13 more
TL;DR: It is shown that under conditions where other copper complexes kill human hepatoma cells, Cu(I)-L-histidine is an effective catalyst for CuAAC labeling of live cells following metabolic incorporation of an alkyne-labeled sugar into glycosylated proteins expressed on the cell surface.
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Chemical contrast for imaging living systems: molecular vibrations drive CARS microscopy
John Paul Pezacki,Jessie A. Blake,Jessie A. Blake,Dana C. Danielson,Dana C. Danielson,David C. Kennedy,Rodney K. Lyn,Rodney K. Lyn,Ragunath Singaravelu,Ragunath Singaravelu +9 more
TL;DR: The nonlinear variant of Raman spectroscopy, coherent anti-Stokes Raman scattering (CARS) microscopy, combines powerful Raman signal enhancement with several other advantages such as label-free detection and has been used to image various cellular processes including host-pathogen interactions and lipid metabolism.
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Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice
TL;DR: Using high-density oligonucleotide arrays, the gene-expression program in the livers of mice after partial hepatectomy is examined to provide a detailed and comprehensive map of the initial priming stage of liver regeneration.
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Three-Mode Electrochemical Sensing of Ultralow MicroRNA Levels
Mahmoud Labib,Nasrin Khan,Shahrokh M. Ghobadloo,Jenny Cheng,John Paul Pezacki,John Paul Pezacki,Maxim V. Berezovski +6 more
TL;DR: A three-mode electrochemical sensor for detection and quantitation of ultralow levels of miRNAs in a wide dynamic range of measured concentrations and the H- and P-SENS were successfully employed for direct detection and profiling of three endogenous mi RNAs in human serum.