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Danhua Zhang
Researcher at Zhejiang University
Publications - 10
Citations - 60
Danhua Zhang is an academic researcher from Zhejiang University. The author has contributed to research in topics: Medicine & Gut flora. The author has an hindex of 1, co-authored 3 publications receiving 3 citations.
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Journal ArticleDOI
Multi-omics analyses of serum metabolome, gut microbiome and brain function reveal dysregulated microbiota-gut-brain axis in bipolar depression
Zhiming Li,Jianbo Lai,Peifen Zhang,Jiahong Ding,Jiajun Jiang,Chuanfa Liu,Huimin Huang,Hefu Zhen,Caixi Xi,Yuzhe Sun,Lingling Wu,Lifang Wang,Xingle Gao,Yan Li,Yaoyang Fu,Zhuye Jie,Shenghui Li,Danhua Zhang,Yiqing Chen,Yiyi Zhu,Shaojia Lu,Jing Lu,Dandan Wang,Hetong Zhou,Xiu-bai Yuan,Xue Lin,Lijuan Pang,Manli Huang,Huanming Yang,Wenwei Zhang,Susanne Brix,Karsten Kristiansen,Xueqin Song,Chao Nie,Shaohua Hu +34 more
TL;DR: This study combines gut microbiota and neuroactive metabolites with brain functional connectivity with neuroimaging studies to reveal potential signalling pathways from the microbiota to the gut and the brain, which may have a role in the pathophysiology of BD.
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Gut microbial clues to bipolar disorder: State-of-the-art review of current findings and future directions.
Jianbo Lai,Jiajun Jiang,Peifen Zhang,Caixi Xi,Lingling Wu,Xingle Gao,Danhua Zhang,Yanli Du,Qunxiao Li,Xiangyuan Diao,Shaojia Lu,Zheng Wang,Xueqin Song,Shaohua Hu +13 more
TL;DR: The concept of MGB axis is introduced, previous findings in human studies associated with bipolar disorder are focused on, and a research framework linking gut microbiome to determinants and health‐related outcomes in BD is proposed.
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Gut Microbiota – A Potential Contributor in the Pathogenesis of Bipolar Disorder
Peifen Zhang,Ling-zhuo Kong,Huimin Huang,Yanmeng Pan,Danhua Zhang,Jiajun Jiang,Yuting Shen,Caixi Xi,Jianbo Lai,Chee H. Ng,Shaohua Hu +10 more
TL;DR: A review of the relationship between the GBA and brain function, the composition and changes of gut microbiota in patients with BD, and the potential role of GBA-related pathway in the pathogenesis of BD is explored to provide new ideas for the future etiology research and drug development.
Journal ArticleDOI
Sex difference in prebiotics on gut and blood–brain barrier dysfunction underlying stress‐induced anxiety and depression
Jiajun Jiang,Yaoyang Fu,Anying Tang,Xingle Gao,Danhua Zhang,Yuting Shen,Tingting Mou,Shaohua Hu,Jingfang Gao,Jianbo Lai +9 more
TL;DR: In this paper , the authors explored whether prebiotics administration during chronic stress prevented depression-like and anxiety-like behavior in a sex-specific manner and the mechanism of behavioral differences caused by sex.
Journal ArticleDOI
Impaired blood-brain barrier in the microbiota-gut-brain axis: Potential role of bipolar susceptibility gene TRANK1
Lai Jianbo,Jiajun Jiang,Peifen Zhang,Caixi Xi,Lingling Wu,Xingle Gao,Yaoyang Fu,Danhua Zhang,Yiqing Chen,Huimin Huang,Yiyi Zhu,Hu Shaohua +11 more
TL;DR: In this article, the influence of intestine microbiota on the expression of bipolar gene TRANK1 was studied and it was shown that intestine microbiota-dependent type 1 interferon signalling is sufficient to induce the over-expression of TRANK 1, consequently causing the compromise of BBB integrity and facilitating the entrance of inflammatory mediators into the brain.