D
Daniel A. Ryan
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 5
Citations - 563
Daniel A. Ryan is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Glycosyl & Chemical glycosylation. The author has an hindex of 4, co-authored 5 publications receiving 497 citations.
Papers
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Journal ArticleDOI
Digoxin and its derivatives suppress Th17 cell differentiation by antagonizing RORγt activity
Jun R. Huh,Monica W.L. Leung,Pengxiang Huang,Daniel A. Ryan,Michael R. Krout,Raghu R. V. Malapaka,Jonathan Chow,Nicolas Manel,Nicolas Manel,Maria Ciofani,Sangwon V. Kim,Adolfo Cuesta,Fabio R. Santori,Juan J. Lafaille,H. Eric Xu,David Y. Gin,Fraydoon Rastinejad,Dan R. Littman +17 more
TL;DR: In this article, the cardiac glycoside digoxin was identified as a specific inhibitor of RORγt transcriptional activity, which is required for induction of IL-17 transcription and for the manifestation of T(H)17-dependent autoimmune disease in mice.
Journal ArticleDOI
Ring-Opening of Aziridine-2-Carboxamides with Carbohydrate C1-O-Nucleophiles. Stereoselective Preparation of α- and β-O-Glycosyl Serine Conjugates
Daniel A. Ryan,David Y. Gin +1 more
TL;DR: The stereoselective formation of the alpha-GalNAc-Ser linkage via the ring opening of aziridine-2-carboxamides with pyranose C1-O-nucleophiles is described, which led to the development of the o-allylbenzyl (ABn) moiety as a new C-terminus carboxyl protective group.
Patent
STEROID COMPOUNDS AS RORγt MODULATORS AND USES THEREOF
TL;DR: Steroid compounds may be prepared as pharmaceutical compositions, and may be used for the treatment or prevention of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.
Patent
STEROID COMPOUNDS AS RORyt MODULATORS AND USES THEREOF
TL;DR: Steroid compounds are disclosed that have a formula represented by the following: as mentioned in this paper and wherein m, n, t, u1, u2, v1, v2, R 1a, R 1b, R 2a,R 2b, R 3c, R 3d, and Y are as described herein.