D
Daniel F Q Smith
Researcher at Johns Hopkins University
Publications - 16
Citations - 220
Daniel F Q Smith is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Biology & Galleria mellonella. The author has an hindex of 3, co-authored 7 publications receiving 84 citations.
Papers
More filters
Journal ArticleDOI
Listeria monocytogenes virulence factors, including listeriolysin O, are secreted in biologically active extracellular vesicles
Carolina Coelho,Lisa M. Brown,Maria Maryam,Raghav Vij,Daniel F Q Smith,Meagan C. Burnet,Jennifer E. Kyle,Heino M. Heyman,Jasmine Ramirez,Rafael Prados-Rosales,Grégoire Lauvau,Ernesto S. Nakayasu,Nathan R. Brady,Anne Hamacher-Brady,Isabelle Coppens,Arturo Casadevall,Arturo Casadevall +16 more
TL;DR: These findings demonstrate that L. monocytogenes uses EVs for toxin release and implicate these structures in mammalian cytotoxicity, and show that dynamic lipid structures are released from L.monocyTogenes during infection.
Book ChapterDOI
The Role of Melanin in Fungal Pathogenesis for Animal Hosts.
TL;DR: Melanin allows fungi to neutralize the microbicidal oxidative bursts of the authors' innate immune system, bind and inactivate to antimicrobial peptides and enzymes, sequester antifungal pharmaceuticals, and create a shield to block immune recognition of the fungus.
Journal ArticleDOI
Glyphosate inhibits melanization and increases susceptibility to infection in insects.
Daniel F Q Smith,Emma Camacho,Raviraj Thakur,Alexander J. Barron,Yuemei Dong,George Dimopoulos,Nichole A. Broderick,Arturo Casadevall +7 more
TL;DR: In this article, the authors demonstrate that glyphosate has deleterious effects on insect health in two evolutionary distant species, Galleria mellonella (Lepidoptera: Pyralidae) and Anopheles gambiae (Diptera: Culicidae), suggesting a broad effect in insects.
Journal ArticleDOI
Fungal immunity and pathogenesis in mammals versus the invertebrate model organism Galleria mellonella.
TL;DR: In this paper, the authors provide comprehensive comparisons between fungal pathogenesis in mammals and G. mellonella from immunological and virulence perspectives, including findings from other well-studied Lepidoptera.
Journal ArticleDOI
A glycan FRET assay for detection and characterization of catalytic antibodies to the Cryptococcus neoformans capsule
Conor J. Crawford,Conor J. Crawford,Maggie P. Wear,Daniel F Q Smith,Clotilde d’Errico,Scott A McConnell,Arturo Casadevall,Stefan Oscarson +7 more
TL;DR: In this article, the use of a glycan microarray allowed epitope mapping of several monoclonal antibodies (mAbs) against the capsule of Cryptococcus neoformans from this, which were used to discover antibodies with innate glycosidase activity and analyze their enzyme kinetics.