Listeria monocytogenes virulence factors, including listeriolysin O, are secreted in biologically active extracellular vesicles
Carolina Coelho,Lisa M. Brown,Maria Maryam,Raghav Vij,Daniel F Q Smith,Meagan C. Burnet,Jennifer E. Kyle,Heino M. Heyman,Jasmine Ramirez,Rafael Prados-Rosales,Grégoire Lauvau,Ernesto S. Nakayasu,Nathan R. Brady,Anne Hamacher-Brady,Isabelle Coppens,Arturo Casadevall,Arturo Casadevall +16 more
TLDR
These findings demonstrate that L. monocytogenes uses EVs for toxin release and implicate these structures in mammalian cytotoxicity, and show that dynamic lipid structures are released from L.monocyTogenes during infection.About:
This article is published in Journal of Biological Chemistry.The article was published on 2019-01-25 and is currently open access. It has received 92 citations till now. The article focuses on the topics: Listeriolysin O & Listeria monocytogenes.read more
Citations
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The Diverse Functional Roles of Elongation Factor Tu (EF-Tu) in Microbial Pathogenesis.
TL;DR: The structural studies indicate that short linear motifs in surface exposed, non-conserved regions of the molecule may play a key role in the moonlighting functions ascribed to this ancient, highly abundant protein.
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Extracellular Vesicle Biogenesis and Functions in Gram-Positive Bacteria.
Paul Briaud,Ronan K. Carroll +1 more
TL;DR: The latest findings on the biogenesis and functions of EVs from Gram-positive bacteria are reviewed and key areas for future research are identified.
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Orchestration of human macrophage NLRP3 inflammasome activation by Staphylococcus aureus extracellular vesicles.
TL;DR: It is reported that EVs purified from a community-associated methicillin-resistant Staphylococcus aureus strain were internalized by human macrophages by an endocytic process, highlighting the role of EVs as a delivery system for bacterial virulence determinants.
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Microbiota-derived extracellular vesicles in interkingdom communication in the gut.
TL;DR: In this article, the authors review current knowledge on microbiota EVs and specifically highlight their role in controlling host metabolism, intestinal barrier integrity and immune training, and highlight their importance in the development of the human intestine.
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Answers to naysayers regarding microbial extracellular vesicles.
TL;DR: In this review, doubts that have been verbalized to us and answers to counter them are provided to highlight the most pressing topics in the authors' understanding of the biological processes underlying these structures.
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