D
Daniel Griffith
Researcher at Washington University in St. Louis
Publications - 15
Citations - 550
Daniel Griffith is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 5, co-authored 9 publications receiving 156 citations. Previous affiliations of Daniel Griffith include University of Washington & University of Wisconsin-Madison.
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Journal ArticleDOI
The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA.
Jasmine Cubuk,Jhullian J. Alston,J. Jeremías Incicco,Sukrit Singh,Melissa D. Stuchell-Brereton,Michael D. Ward,Maxwell I. Zimmerman,Neha Vithani,Daniel Griffith,Jason A. Wagoner,Gregory R. Bowman,Kathleen B. Hall,Andrea Soranno,Alex S. Holehouse +13 more
TL;DR: The SARS-CoV-2 nucleocapsid (N) protein is an abundant RNA-binding protein critical for viral genome packaging, yet the molecular details that underlie this process are poorly understood as discussed by the authors.
Posted ContentDOI
The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA
Jasmine Cubuk,Jhullian J. Alston,J. Jeremías Incicco,Sukrit Singh,Melissa D. Stuchell-Brereton,Michael D. Ward,Maxwell I. Zimmerman,Neha Vithani,Daniel Griffith,Jason A. Wagoner,Gregory R. Bowman,Kathleen B. Hall,Andrea Soranno,Alex S. Holehouse +13 more
TL;DR: A simple model in which symmetry breaking through specific binding sites promotes the formation of metastable single-RNA condensate, as opposed to large multi-RNA phase separated droplets is proposed, suggesting that RNA compaction to form dynamic single-genome condensates may underlie the early stages of genome packaging.
Journal ArticleDOI
Metapredict: a fast, accurate, and easy-to-use predictor of consensus disorder and structure.
TL;DR: Metapredict as mentioned in this paper uses a bidirectional recurrent neural network trained on consensus disorder scores from 12 proteomes to predict disordered proteins and protein regions in biological function, which is the most accurate consensus disorder predictor currently available.
Journal ArticleDOI
Clustering of Aromatic Residues in Prion-like Domains Can Tune the Formation, State, and Organization of Biomolecular Condensates.
TL;DR: In this paper, the authors investigated the role of prion-like domains (PLDs) in the formation of Balbiani bodies in Xenopus laevis and found that the Velo1 design with evenly spaced aromatic residues shows rapid internal dynamics, as probed by fluorescent recovery after photobleaching.
Journal ArticleDOI
Imbalance of tyrosine by modulating TyrA arogenate dehydrogenases impacts growth and development of Arabidopsis thaliana.
Marcos V. V. de Oliveira,Xing Jin,Xuan Chen,Daniel Griffith,Sai Batchu,Sai Batchu,Hiroshi A. Maeda +6 more
TL;DR: The results revealed that TyrA1 and TyrA2 have distinct and overlapping functions in flower and leaf development, respectively, and that imbalance of tyrosine, caused by altered TyrA activity and regulation, impacts growth and development of Arabidopsis.