Daniel J. Fazakerley

TL;DR: The discovery of the involvement of Rab3 and Noc2 in an insulin-regulated step in GLUT4 translocation suggests that the control of this translocation process is unexpectedly similar to regulated secretion and particularly pancreatic insulin-vesicle release.

TL;DR: In this article , the authors leveraged the metabolic diversity of different dietary exposures and discrete inbred mouse strains to uncover pathways involved in insulin resistance, specifically in these tissues, and leveraged this information to reveal that muscle insulin resistance was driven by gene-by-environment interactions and was strongly correlated with hyperinsulinemia and decreased levels of ten key glycolytic enzymes.

TL;DR: The response of a population to insulin signaling is underpinned by considerable single-cell heterogeneity that is largely driven by variance in gene/protein expression between cells.

TL;DR: The results show that the UV contained in sunlight has the potential to prevent and treat chronic disease at sites distant from irradiated skin.

TL;DR: KSR-LIVE as mentioned in this paper is an open-access algorithm that allows users to dissect phosphorylation signaling within a specific biological context, with the potential to be included in the standard analysis workflow for studying temporal highthroughput signal transduction data.