D
Daniel J. Fazakerley
Researcher at University of Sydney
Publications - 74
Citations - 3089
Daniel J. Fazakerley is an academic researcher from University of Sydney. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 25, co-authored 63 publications receiving 2232 citations. Previous affiliations of Daniel J. Fazakerley include University of Cambridge & National Institutes of Health.
Papers
More filters
Journal ArticleDOI
Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation.
Daniel J. Fazakerley,Annabel Y. Minard,James R. Krycer,Kristen C. Thomas,Jacqueline Stöckli,Dylan J. Harney,James G. Burchfield,Ghassan J. Maghzal,Ghassan J. Maghzal,Stuart T. Caldwell,Richard C. Hartley,Roland Stocker,Roland Stocker,Michael P. Murphy,David E. James +14 more
TL;DR: It is concluded that elevated mitochondrial oxidants rapidly impair insulin-regulated GLUT4 translocation and significantly contribute to insulin resistance and that MitoPQ is an ideal tool for studying the link between mitochondrial oxidative stress and regulatedGLUT4 trafficking.
Journal ArticleDOI
Selective insulin resistance in adipocytes.
Shi-Xiong Tan,Kelsey H. Fisher-Wellman,Daniel J. Fazakerley,Yvonne Ng,Himani Pant,Jia Li,Christopher C. Meoli,Adelle C.F. Coster,Jacqueline Stöckli,David E. James +9 more
TL;DR: It is concluded that insulin resistance in adipose tissue is highly selective for glucose metabolism and likely involves a defect in one of the components regulating GLUT4 translocation to the cell surface in response to insulin.
Journal ArticleDOI
Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity.
Lindsay E. Wu,Lindsay E. Wu,Dorit Samocha-Bonet,Dorit Samocha-Bonet,P. Tess Whitworth,Daniel J. Fazakerley,Nigel Turner,Nigel Turner,Trevor J. Biden,Trevor J. Biden,David E. James,David E. James,James Cantley,James Cantley,James Cantley +14 more
TL;DR: It is shown that fatty acid binding protein 4 (FABP4/aP2) is an adipokine released from adipocytes under obesogenic conditions, such as hypoxia, to augment insulin secretion, and that FABP 4 and insulin form an endocrine loop coordinating the β-cell response to obesity.
Journal ArticleDOI
Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle.
Evan P. Taddeo,Rhianna C. Laker,David S. Breen,Yasir N. Akhtar,Brandon M. Kenwood,Jason A. Liao,Mei Zhang,Daniel J. Fazakerley,Jose L. Tomsig,Thurl E. Harris,Susanna R. Keller,Jenny D.Y. Chow,Kevin R. Lynch,M. Chokki,Jeffery D. Molkentin,Nigel Turner,David E. James,David E. James,Zhen Yan,Kyle L. Hoehn +19 more
TL;DR: Insulin resistance is associated with mitochondrial dysfunction, but the mechanism by which mitochondria inhibit insulin-stimulated glucose uptake into the cytoplasm is unclear and the mPTP is placed at a critical intersection between alterations in mitochondrial function and insulin resistance in skeletal muscle.
Journal ArticleDOI
mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes
Annabel Y. Minard,Shi-Xiong Tan,Pengyi Yang,Daniel J. Fazakerley,Westa Domanova,Benjamin L. Parker,Sean J. Humphrey,Raja Jothi,Jacqueline Stöckli,David E. James +9 more
TL;DR: It is suggested that mTORC1 may act to facilitate FGF21-mediated health benefits in vivo, including UCP1 and F GF21 induction, increased adiponectin secretion, and enhanced glucose uptake without any adverse effects on insulin action.