D
Daniel J. Lee
Researcher at Johns Hopkins University
Publications - 9
Citations - 3876
Daniel J. Lee is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Loss of heterozygosity & Head and neck squamous-cell carcinoma. The author has an hindex of 8, co-authored 9 publications receiving 3803 citations. Previous affiliations of Daniel J. Lee include UMass Memorial Health Care.
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Journal ArticleDOI
5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers.
Adrian Merlo,James G. Herman,Li Mao,Daniel J. Lee,Edward Gabrielson,Peter C. Burger,Stephen B. Baylin,David Sidransky +7 more
TL;DR: De novo methylation of the 5′ CpG island of p16 was found in approximately 20% of different primary neoplasms, but not in normal tissues, potentially representing a common pathway of tumour suppressor gene inactivation in human cancers.
Journal Article
Genetic progression model for head and neck cancer: Implications for field cancerization
Joseph A. Califano,Peter van der Riet,William H. Westra,Homaira Nawroz,Gary L. Clayman,Steven Piantadosi,Russell L. Corio,Daniel J. Lee,Benjamin Greenberg,Wayne M. Koch,David Sidransky +10 more
TL;DR: The local clinical phenomenon of field cancerization seems to involve the expansion and migration of clonally related preneoplastic cells within normal mucosal cells surrounding preinvasive and microinvasive lesions and thus appear to arise from a single progenitor clone.
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Microsatellite alterations as clonal markers for the detection of human cancer.
TL;DR: This study demonstrates that appropriately selected microsatellite loci are commonly altered in many cancers and can serve as clonal markers for their detection.
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Effects of cytomegalovirus (CMV) related deafness on pediatric cochlear implant outcomes
TL;DR: It is shown that cochlear implants can provide useful speech comprehension to patients with CMV-related deafness, and underscores the importance of a multidisciplinary rehabilitation program following implantation in these patients at risk for cognitive delay.
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Clinical and histopathologic features of recurrent vestibular schwannoma (acoustic neuroma) after stereotactic radiosurgery.
TL;DR: The variable fibrosis in the cerebellopontine angle and lack of radiation changes seen histopathologically in irradiated vestibular schwannoma suggest that a uniform treatment effect was not achieved in these cases.