抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Objective To describe the psychometric properties of the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version (K-SADS-PL) interview, which surveys additional disorders not assessed in prior K-SADS, contains improved probes and anchor points, includes diagnosis-specific impairment ratings, generates DSM-III-R and DSM-IV diagnoses, and divides symptoms surveyed into a screening interview and five diagnostic supplements. Method Subjects were 55 psychiatric outpatients and 11 normal controls (aged 7 through 17 years). Both parents and children were used as informants. Concurrent validity of the screen criteria and the K-SADS-PL diagnoses was assessed against standard self-report scales. Interrater ( n = 15) and test-retest ( n = 20) reliability data were also collected (mean retest interval: 18 days; range: 2 to 38 days). Results Rating scale data support the concurrent validity of screens and K-SADS-PL diagnoses. Interrater agreement in scoring screens and diagnoses was high (range: 93% to 100%). Test-retest reliability κ coefficients were in the excellent range for present and/or lifetime diagnoses of major depression, any bipolar, generalized anxiety, conduct, and oppositional defiant disorder (.77 to 1.00) and in the good range for present diagnoses of posttraumatic stress disorder and attention-deficit hyperactivity disorder (.63 to .67). Conclusion Results suggest the K-SADS-PL generates reliable and valid child psychiatric diagnoses. J. Am. Acad. Child Adolesc. Psychiatry , 1997, 36(7): 980–988.

Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): Initial Reliability and Validity Data

https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(12)61729-2.pdf

Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

The Diagnostic and Statistical Manual of Mental Disorders, fourth edition, text revision (DSM-IV-TR) (American Psychiatric Association [APA], 2000) is a compendium of mental disorders, a listing of the criteria used to diagnose them, and a detailed system for their definition, organization, and classification. Put simply, it is the primary diagnostic manual for mental health professionals in the United States and much of the Western world. Diagnosis refers to the identification and labeling of a mental disorder by examination and analysis. Mental health professionals diagnose individuals based on the symptoms that they report experiencing and the signs of illness with which they present. The DSM-IV-TR aids professionals in understanding and diagnosing mental disorders through its provision of explicit diagnostic criteria and an official classification system.


Keywords:

diagnosis;
classification;
mental illness;
psychopathology

Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR)

Attachment--and loss.

It has been reported that many molecules could inhibit the aggregation of Aβ (amyloid-β) through suppressing either primary nucleation, secondary nucleation, or elongation processes. In order to suppress multiple pathways of Aβ aggregation, we screened 23 small molecules and found two types of inhibitors with different inhibiting mechanisms based on chemical kinetics analysis. Trp-glucose conjugates (AS2) could bind with fibril ends while natural products (D3 and D4) could associate with monomers. A cocktail of these two kinds of molecules achieved co-inhibition of various fibrillar species and avoid unwanted interference.

Rational Design of a Cocktail of Inhibitors against Aβ Aggregation.

In this paper, we review the impact of visual impairment on social adaptation of older visually impaired adults. The review begins with statistics documenting increased visual problems among the elderly, concomitant with enhanced longevity. The next section provides a summary of assessment and treatment of the social adaptation of younger and middle-aged adults suffering from visual loss. The following section is a survey of extant literature on assessment and treatment of social functioning of older visually impaired individuals. The last section of the paper delineates further research needs, detailing a controlled outcome study that would place the field on a firmer empirical base than is available at present.

Social Adaptation in Older Visually Impaired Adults: Some Comments

The aim of the present study was to explore end-of-life health care attitudes among younger and older sexually diverse women. Self-identified lesbian and heterosexual older women as well as lesbian and heterosexual middle-aged women were recruited. Results indicated that lesbian women held significantly more positive beliefs about hospice services and the role of alternative medicines in health care. No differences among sexual orientation were found for comfort discussing pain management but heterosexual women reported a significantly greater desire for life-sustaining treatments in the event of an incurable disease and severe life-limiting conditions (eg, feeding tube, life support, no brain response). Additionally, as expected, older women in this study held more positive beliefs about hospice and more comfort discussing pain management than middle-aged women.

Views of Hospice and Palliative Care Among Younger and Older Sexually Diverse Women

Diet-induced mating preference was initially observed by Dodd (1). Subsequently, we reported that diet-induced mating preference occurred in Drosophila melanogaster. Treatment of the flies with antibiotics abolished the mating preference, suggesting that fly-associated commensal bacteria were responsible for the phenomenon (2). The hypothesis was confirmed when it was shown that colonizing antibiotic-treated flies with Lactobacillus plantarum reestablished mating preference in multiple-choice mating assays with CMY (0.65% agar, 7.6% cornmeal, 7.6% molasses, 5% inactivated brewer’s yeast, 0.1% methyl-4-hydroxybenzoate, 0.76% ethanol, and 0.4% propionic acid) flies. Furthermore, analytical studies indicated that the flies grown on different media had distinct levels of cuticular hydrocarbon sex pheromones. The difference in their levels was reduced when the flies were treated with antibiotics.

https://www.pnas.org/content/pnas/115/10/E2153.full.pdf

Diet-induced mating preference in Drosophila.

The present study used an informant method of psychiatric assessment to evaluate Saddam Hussein, and these results were compared to a posthumous assessment of Adolf Hitler. Eleven Iraqi adults who lived under Hussein’s influence for a median of 24 years completed the Coolidge Axis II Inventory, a measure of 14 personality disorders. The mean consensus among the 11 raters was r = .57. It revealed that Hussein probably reached diagnostic threshold for the sadistic (T score M= 81.0), paranoid (T score M= 79.3), antisocial (T score M= 77.4), and narcissistic (T score M= 74.2) personality disorders. The correlation between the consensus profile for Hussein and a consensus profile of 5 Hitler experts was r = .79, indicating a very strong similarity between the two profiles. It was concluded that Saddam Hussein had many of the same personality disorders or their features as Adolf Hitler, although sadistic features were stronger in Hussein than Hitler. It appeared that a “Big Four” personality disorders constellation emerged for these two dictators, and they were sadistic, antisocial, paranoid, and narcissistic. It was also found that Hussein might have had some traits or features of paranoid schizophrenia. Implications for diplomacy and negotiations with persons with similar personality profiles are proffered.

/pdf/was-saddam-hussein-like-adolf-hitler-a-personality-disorder-1jqznxm4u3.pdf

Daniel L. Segal

Papers

Rational Design of a Cocktail of Inhibitors against Aβ Aggregation.

Social Adaptation in Older Visually Impaired Adults: Some Comments

Views of Hospice and Palliative Care Among Younger and Older Sexually Diverse Women

Diet-induced mating preference in Drosophila.

Was Saddam Hussein Like Adolf Hitler? A Personality Disorder Investigation