抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Objective To describe the psychometric properties of the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version (K-SADS-PL) interview, which surveys additional disorders not assessed in prior K-SADS, contains improved probes and anchor points, includes diagnosis-specific impairment ratings, generates DSM-III-R and DSM-IV diagnoses, and divides symptoms surveyed into a screening interview and five diagnostic supplements. Method Subjects were 55 psychiatric outpatients and 11 normal controls (aged 7 through 17 years). Both parents and children were used as informants. Concurrent validity of the screen criteria and the K-SADS-PL diagnoses was assessed against standard self-report scales. Interrater ( n = 15) and test-retest ( n = 20) reliability data were also collected (mean retest interval: 18 days; range: 2 to 38 days). Results Rating scale data support the concurrent validity of screens and K-SADS-PL diagnoses. Interrater agreement in scoring screens and diagnoses was high (range: 93% to 100%). Test-retest reliability κ coefficients were in the excellent range for present and/or lifetime diagnoses of major depression, any bipolar, generalized anxiety, conduct, and oppositional defiant disorder (.77 to 1.00) and in the good range for present diagnoses of posttraumatic stress disorder and attention-deficit hyperactivity disorder (.63 to .67). Conclusion Results suggest the K-SADS-PL generates reliable and valid child psychiatric diagnoses. J. Am. Acad. Child Adolesc. Psychiatry , 1997, 36(7): 980–988.

Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): Initial Reliability and Validity Data

https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(12)61729-2.pdf

Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

The Diagnostic and Statistical Manual of Mental Disorders, fourth edition, text revision (DSM-IV-TR) (American Psychiatric Association [APA], 2000) is a compendium of mental disorders, a listing of the criteria used to diagnose them, and a detailed system for their definition, organization, and classification. Put simply, it is the primary diagnostic manual for mental health professionals in the United States and much of the Western world. Diagnosis refers to the identification and labeling of a mental disorder by examination and analysis. Mental health professionals diagnose individuals based on the symptoms that they report experiencing and the signs of illness with which they present. The DSM-IV-TR aids professionals in understanding and diagnosing mental disorders through its provision of explicit diagnostic criteria and an official classification system.


Keywords:

diagnosis;
classification;
mental illness;
psychopathology

Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR)

Attachment--and loss.

http://www.coolidgetests.org/content/CATI/Coolidge%20et%20al%202009-Working%20memory%20deficits%20in%20personality%20disorder%20traits.pdf

Working memory deficits in personality disorder traits: A preliminary investigation in a nonclinical sample

The von Hippel-Lindau (VHL) syndrome is a rare inherited cancer, caused by mutations in the VHL gene, many of which render the VHL protein (pVHL) unstable pVHL is a tumor-suppressor protein implicated in a variety of cellular processes, most notably in response to changes in oxygen availability, due to its role as part of an E3-ligase complex which targets the hypoxia-inducible factor (HIF) for degradation Previously we reported, using in silico and in vitro analyses, that common oncogenic VHL mutations render pVHL less stable than the wild-type protein, distort its core domain and as a result reduce the ability of the protein to bind its target HIF-1α Among various chemical chaperones tested, arginine was the most effective in refolding mutant of pVHL Here we examined the consequences of administering L- or D-arginine to a Drosophila VHL model and to human renal carcinoma cells, both expressing misfolded versions of human pVHL Arginine treatment increased pVHL solubility in both models and increased the half-life of the mutant pVHL proteins in the cell culture In both models, L- as well as D-arginine enhanced the ability of wild-type pVHL and certain misfolded mutant versions of pVHL to bind ODD, the HIF-derived target peptide, reflecting restoration of pVHL function Moreover, continuous feeding of Drosophila expressing misfolded versions of pVHL either L- or D-arginine rich diet rescued their lethal phenotype Collectively, these in vivo results suggest that arginine supplementation should be examined as a potential novel treatment for VHL cancer syndrome

Arginine refolds, stabilizes, and restores function of mutant pVHL proteins in animal model of the VHL cancer syndrome.

Barriers to Mental Health Services Scale

The Levels of Personality Functioning Scale-Brief Form 2.0 (LPFS-BF 2.0) is a new measure of personality functioning according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition's, alternative model of personality disorders, containing a total personality functioning score and two subscales (Self and Interpersonal). The LPFS-BF 2.0 has limited evidence of validity among older adults. Subsequently, this study examined relationships between the LPFS-BF 2.0 and anxiety, interpersonal functioning, and normative personality traits to establish convergent validity. In all, 130 community-dwelling older adults (Mage = 64.61) completed the LPFS-BF 2.0, Geriatric Anxiety Scale, Circumplex Scales of Interpersonal Problems (CSIP), and Big Five Inventory-2 (BFI-2). Internal consistency (Cronbach's α) was acceptable to good for each of the LPFS-BF 2.0 scale scores (Self, α = .74; Interpersonal, α = .85; Total Personality Functioning, α = .79). Correlations were computed between the LPFS-BF 2.0 scales and the Geriatric Anxiety Scale, CSIP, and BFI-2. Overall, significant correlations were detected in expected directions. Additionally, to further establish convergent validity, regression analyses were conducted with the CSIP and BFI-2 scales predicting each of the LPFS-BF 2.0 scales. The models accounted for significant variance, and significant predictors were found in anticipated and theoretically consistent directions. Results provide strong but initial psychometric support for the use of the LPFS-BF 2.0 as an assessment tool for measuring personality functioning among older adults. An implication is that this measure may be used to identify important personality features that are part of a full assessment of personality pathology. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Psychometric evaluation of the Levels of Personality Functioning Scale—Brief Form 2.0 among older adults.

Posttraumatic stress disorder (PTSD) is a mental disorder that is known to have deleterious psychological, physical, and social impacts on individuals. Recognition of PTSD in older adults is difficult due to the complicated presentation taking into account that PTSD symptoms may be masked by other psychiatric and/or somatic diagnoses that are more common in older adults. Furthermore, some older adults may underreport their PTSD symptoms, and the relationship between current symptoms and distant traumas may be difficult to detect. Limited empirical research has been done on the manifestation, course, and treatment of PTSD in older adults. In this article, the literature on PTSD in older adults is reviewed, including discussion of common diagnostic problems, illustrated by a case report of an older woman with late-onset PTSD after a cerebral vascular accident (CVA). In conclusion, identifying PTSD in older adults can be difficult. However, detecting PTSD in older adults is critically important so that possibly hidden or masked trauma symptoms can be addressed in treatment, even if there are complicating factors such as a CVA.

Daniel L. Segal

Papers

Working memory deficits in personality disorder traits: A preliminary investigation in a nonclinical sample

Arginine refolds, stabilizes, and restores function of mutant pVHL proteins in animal model of the VHL cancer syndrome.

Barriers to Mental Health Services Scale

Psychometric evaluation of the Levels of Personality Functioning Scale—Brief Form 2.0 among older adults.

Brief Eclectic Psychotherapy for an Older Dutch Woman With Late-Onset Posttraumatic Stress Disorder Complicated by a Cerebral Vascular Accident