D
Daniel Ruggiero
Researcher at Institut national des sciences Appliquées de Lyon
Publications - 11
Citations - 340
Daniel Ruggiero is an academic researcher from Institut national des sciences Appliquées de Lyon. The author has contributed to research in topics: Glycation & Retinal. The author has an hindex of 7, co-authored 9 publications receiving 326 citations.
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Journal ArticleDOI
Advanced glycation end-products induce apoptosis of bovine retinal pericytes in culture: involvement of diacylglycerol/ceramide production and oxidative stress induction
Ulriche Denis,Marc Lecomte,Clarisse Paget,Daniel Ruggiero,Nicolas Wiernsperger,Michel Lagarde +5 more
TL;DR: The hypothesis that AGE might be involved in the disappearance of retinal pericytes by apoptosis is tested, and new biochemical targets involved in pericyte loss are identified which can provide new therapeutic perspectives in diabetic retinopathy.
Journal ArticleDOI
Albumin antioxidant capacity is modified by methylglyoxal.
Patrice Faure,Lysiane Troncy,Marc Lecomte,Nicolas Wiernsperger,Michel Lagarde,Daniel Ruggiero,Serge Halimi +6 more
TL;DR: The results suggest that deleterious effects induced by carbonyl stress in diabetes could also originate from a loss of albumin antioxidant capacity by dicarbonyl compound attack.
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Docosahexaenoic Acid Is a Major n‐3 Polyunsaturated Fatty Acid in Bovine Retinal Microvessels
TL;DR: This high percentage of polyunsaturated fatty acids in retinal microvessels should allow the hypothesis that oxidation products derived from these fatty acids may be involved in the pathogenic process leading to diabetic retinopathy to be tested.
Journal Article
Involvement of cell-cell interactions in the pathogenesis of diabetic retinopathy.
TL;DR: An overall, nonexhaustive description of some types of cellular interactions that may underlie the pathogenic mechanisms involved in flow and growth changes leading to diabetic retinopathy is provided.
Journal ArticleDOI
Involvement of caspase-10 in advanced glycation end-product-induced apoptosis of bovine retinal pericytes in culture
TL;DR: Results strongly suggest that caspase-10, but not casp enzyme-8, might be involved in the early phase of AGE-induced pericyte apoptosis, in contrast to caspases-9 and -3-like enzymes involved after DAG/ceramide production.