M
Marc Lecomte
Researcher at Institut national des sciences Appliquées de Lyon
Publications - 18
Citations - 912
Marc Lecomte is an academic researcher from Institut national des sciences Appliquées de Lyon. The author has contributed to research in topics: Glycation & Pericyte. The author has an hindex of 12, co-authored 17 publications receiving 880 citations.
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Journal ArticleDOI
Reaction of Metformin with Dicarbonyl Compounds. Possible Implication in the Inhibition of Advanced Glycation End Product Formation
Daniel Ruggiero-Lopez,Marc Lecomte,Gerard Moinet,Gerard Patereau,Michel Lagarde,Nicolas Wiernsperger +5 more
TL;DR: The results suggest that besides its known antihyperglycemic effect, metformin could also decrease AGE formation by reacting with alpha-dicarbonyl compounds, relevant to a potential clinical use of met formin in the prevention of diabetic complications by inhibition of carbonyl stress.
Journal ArticleDOI
Advanced glycation end-products induce apoptosis of bovine retinal pericytes in culture: involvement of diacylglycerol/ceramide production and oxidative stress induction
Ulriche Denis,Marc Lecomte,Clarisse Paget,Daniel Ruggiero,Nicolas Wiernsperger,Michel Lagarde +5 more
TL;DR: The hypothesis that AGE might be involved in the disappearance of retinal pericytes by apoptosis is tested, and new biochemical targets involved in pericyte loss are identified which can provide new therapeutic perspectives in diabetic retinopathy.
Original Contribution ADVANCED GLYCATION END-PRODUCTS INDUCE APOPTOSIS OF BOVINE RETINAL PERICYTES IN CULTURE: INVOLVEMENT OF DIACYLGLYCEROL/CERAMIDE PRODUCTION AND OXIDATIVE STRESS INDUCTION
Ulriche Denis,Marc Lecomte,Clarisse Paget,Daniel Ruggiero,Nicolas Wiernsperger,Michel Lagarde +5 more
TL;DR: In this paper, the authors tested the hypothesis that AGE might be involved in the disappearance of retinal pericytes by apoptosis and further investigated the signaling pathway leading to cell death.
Journal ArticleDOI
Modification of Enzymatic Antioxidants in Retinal Microvascular Cells by Glucose or Advanced Glycation End Products
TL;DR: Differences in antioxidant enzyme activities observed between BREC and BRP, cultured with high concentrations of glucose or AGE, might help to explain their different behavior during the pathogenesis of diabetic retinopathy.
Journal ArticleDOI
Albumin antioxidant capacity is modified by methylglyoxal.
Patrice Faure,Lysiane Troncy,Marc Lecomte,Nicolas Wiernsperger,Michel Lagarde,Daniel Ruggiero,Serge Halimi +6 more
TL;DR: The results suggest that deleterious effects induced by carbonyl stress in diabetes could also originate from a loss of albumin antioxidant capacity by dicarbonyl compound attack.