Daniela Mercatelli

TL;DR: The NOP-eGFP receptor was present in brain of homozygous knock-in animals in concentrations somewhat higher than in wild-type mice and was functional when tested for stimulation of GTPγS binding in vitro and in patch-clamp electrophysiology in dorsal root ganglia (DRG) neurons and hippocampal slices as discussed by the authors.

TL;DR: The aim of this study was to investigate the mechanism of action underlying the nicotine‐suppressive effects of AT‐1001, a high‐affinity and selective α3β4 nAChR antagonist that blocks nicotine self‐administration in rats.

TL;DR: Investigation of whether neuropathic pain is accompanied by prodynorphin (Pdyn) and κ‐opioid receptor (Oprk1) gene expression alterations in selected mouse brain areas indicates that the dynorphinergic system undergoes quite selective alterations involving the corticostriatal circuitry during neuropathicPain, suggesting a contribution to the negative affective component of pain.

TL;DR: A different effect by morphine and fentanyl on MOP mRNA levels is showed that contributes to define the role of MOP gene expression changes in the mechanisms underlying the tolerance.

TL;DR: It is demonstrated that chronic pain leads to plasticity of nAChRs that do not directly facilitate nicotine addictive behaviors, and nicotine potently decreases allodynia, an effect that could lead to increased nicotine consumption in chronic pain subjects.