D
Daniela Perotti
Researcher at University of Milan
Publications - 60
Citations - 1228
Daniela Perotti is an academic researcher from University of Milan. The author has contributed to research in topics: Wilms' tumor & Loss of heterozygosity. The author has an hindex of 17, co-authored 55 publications receiving 961 citations.
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Journal ArticleDOI
The UMBRELLA SIOP-RTSG 2016 Wilms tumour pathology and molecular biology protocol.
Gordan M. Vujanic,Manfred Gessler,Ariadne H. A. G. Ooms,Paola Collini,Aurore Coulomb-L'Hermine,Ellen D'Hooghe,Ronald R. de Krijger,Daniela Perotti,Kathy Pritchard-Jones,Christian Vokuhl,Marry M. van den Heuvel-Eibrink,Norbert Graf +11 more
TL;DR: The pathology panel of the International Society of Paediatric Oncology–Renal Tumour Study Group (SIOP–RSTG) present the pathology and molecular biology protocol for Wilms tumours in the UMBRELLA SIOP-RTSG 2016 protocol, which is a consensus from the SIOP– RTSG pathology panel.
Journal ArticleDOI
Distinct Methylation Changes at the IGF2-H19 Locus in Congenital Growth Disorders and Cancer
Adele Murrell,Yoko Ito,Gaetano Verde,Joanna E. Huddleston,Kathryn Woodfine,Margherita Silengo,Filippo Spreafico,Daniela Perotti,Agostina De Crescenzo,Angela Sparago,Flavia Cerrato,Andrea Riccio +11 more
TL;DR: A model in which DMR0 and IC1 have opposite susceptibilities to global hyper and hypomethylation during tumorigenesis independent of the parent of origin imprint is supported.
Journal ArticleDOI
Different mechanisms cause imprinting defects at the IGF2/H19 locus in Beckwith–Wiedemann syndrome and Wilms' tumour
Flavia Cerrato,Angela Sparago,Gaetano Verde,Agostina De Crescenzo,Valentina Citro,Maria Vittoria Cubellis,Maria Michela Rinaldi,Luigi Boccuto,Giovanni Neri,Cinzia Magnani,Paolo D'Angelo,Paola Collini,Daniela Perotti,Gianfranco Sebastio,Eamonn R. Maher,Andrea Riccio +15 more
TL;DR: The results indicate that methylation-imprinting defects at the IGF2-H19 locus can result from inherited mutations of the IC and have high recurrence risk or arise independently from the sequence context and generally not transmitted to the progeny.
Journal ArticleDOI
Adult Wilms' tumor: A monoinstitutional experience and a review of the literature.
Monica Terenziani,Filippo Spreafico,Paola Collini,Luigi Piva,Daniela Perotti,Marta Podda,Lorenza Gandola,Maura Massimino,Stefano Cereda,Graziella Cefalo,Roberto Luksch,Michela Casanova,Andrea Ferrari,Daniela Polastri,B S Pinuccia Valagussa,Franca Fossati-Bellani +15 more
TL;DR: The authors reviewed their institutional experience regarding adult patients with Wilms' tumor (WT) to assess their clinical characteristics and compliance with respect to children's treatment guidelines.
Journal ArticleDOI
Functional inactivation of the WTX gene is not a frequent event in Wilms' tumors.
Daniela Perotti,Beatrice Gamba,Michele Sardella,Filippo Spreafico,Monica Terenziani,Paola Collini,Andrea Pession,Marilina Nantron,Franca Fossati-Bellani,Paolo Radice +9 more
TL;DR: The findings indicate that previously reported estimates on the proportion of Wilms’ tumors due to WTX alterations should be reconsidered and that WTX has been proposed as a ‘one-hit’ tumor suppressor gene.