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Daniela Weinmann
Researcher at Medical University of Vienna
Publications - 14
Citations - 303
Daniela Weinmann is an academic researcher from Medical University of Vienna. The author has contributed to research in topics: Galectin & Extracellular matrix. The author has an hindex of 6, co-authored 14 publications receiving 220 citations. Previous affiliations of Daniela Weinmann include Ludwig Maximilian University of Munich.
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Journal ArticleDOI
Galectin-1 Couples Glycobiology to Inflammation in Osteoarthritis through the Activation of an NF-κB–Regulated Gene Network
Stefan Toegel,Daniela Weinmann,Sabine André,Sonja M. Walzer,Martin Bilban,Sebastian Schmidt,Catharina Chiari,Reinhard Windhager,Christoph Krall,Idriss M. Bennani-Baiti,Hans-Joachim Gabius +10 more
TL;DR: Immunohistochemical analysis substantiated that Galectin-1 upregulation is associated with osteoarthritic cartilage and subchondral bone histopathology and severity of degeneration, and identifies GalectIn-1 as a master regulator of clinically relevant inflammatory-response genes, working via NF-κB.
Journal ArticleDOI
Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies
Michaela Auer-Grumbach,Stefan Toegel,Maria Schabhüttl,Daniela Weinmann,Catharina Chiari,David L.H. Bennett,Christian Beetz,Dennis Klein,Peter M. Andersen,Ilka Böhme,Regina Fink-Puches,Michael Gonzalez,Matthew B. Harms,William W. Motley,Mary M. Reilly,Wilfried Renner,Sabine Rudnik-Schöneborn,Beate Schlotter-Weigel,Andreas C. Themistocleous,Andreas C. Themistocleous,Jochen H. Weishaupt,Albert C. Ludolph,Thomas Wieland,Feifei Tao,Lisa Abreu,Reinhard Windhager,Manuela Zitzelsberger,Tim M. Strom,Thomas Walther,Thomas Walther,Steven S. Scherer,Stephan Züchner,Rudolf Martini,Jan Senderek +33 more
TL;DR: In this paper, the authors found that late-onset axonal Charcot-Marie-Tooth neuropathy (CMT2) is an autosomal-dominantly inherited condition that manifests in the second half of life and is genetically largely unexplained.
Journal ArticleDOI
Galectin-3 Induces a Pro-degradative/inflammatory Gene Signature in Human Chondrocytes, Teaming Up with Galectin-1 in Osteoarthritis Pathogenesis.
Daniela Weinmann,Karin Schlangen,Sabine André,Sebastian Schmidt,Sonja M. Walzer,Bernd Kubista,Reinhard Windhager,Stefan Toegel,Hans-Joachim Gabius +8 more
TL;DR: The results suggest that a network of endogenous lectins is relevant for initiating this process cascade, and a pro-degradative/inflammatory gene signature under the control of NF-κB is revealed.
Journal ArticleDOI
Galectin-8 induces functional disease markers in human osteoarthritis and cooperates with galectins-1 and -3.
Daniela Weinmann,Michael Kenn,Sebastian Schmidt,Katy Schmidt,Sonja M. Walzer,Bernd Kubista,Reinhard Windhager,Wolfgang Schreiner,Stefan Toegel,Hans-Joachim Gabius +9 more
TL;DR: It is shown that the presence of tandem-repeat-type galectin-8 significantly correlated with cartilage degeneration and that it is secreted by osteoarthritic chondrocytes, and proof-of-principle evidence is provided for an intra-network cooperation of galectins with three types of modular architecture.
Journal ArticleDOI
Compounds from Caesalpinia sappan with anti-inflammatory properties in macrophages and chondrocytes
Monika Mueller,Daniela Weinmann,Stefan Toegel,Wolfgang Holzer,Frank M. Unger,Helmut Viernstein +5 more
TL;DR: In this article, five fractions from the ethanolic extract of Caesalpinia sappan, including episappanol (1), protosappanin C (2), brazilin (3), (iso-)protosappansin B (4), and sappanol (5), were tested for their anti-inflammatory effects in two different cell lines.