D
Daphne A. Haas-Kogan
Researcher at Brigham and Women's Hospital
Publications - 286
Citations - 14986
Daphne A. Haas-Kogan is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Radiation therapy & Glioma. The author has an hindex of 58, co-authored 257 publications receiving 12773 citations. Previous affiliations of Daphne A. Haas-Kogan include University of California & University of California, San Francisco.
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Journal ArticleDOI
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.
Ingo K. Mellinghoff,Maria Y. Wang,Igor Vivanco,Daphne A. Haas-Kogan,Shaojun Zhu,Ederlyn Q. Dia,Kan V. Lu,Koji Yoshimoto,Julie H. Y Huang,Dennis J. Chute,Bridget L. Riggs,Steve Horvath,Linda M. Liau,Webster K. Cavenee,P. Nagesh Rao,Rameen Beroukhim,Rameen Beroukhim,Rameen Beroukhim,Timothy C. Peck,Timothy C. Peck,Timothy C. Peck,Jeffrey C. Lee,Jeffrey C. Lee,Jeffrey C. Lee,William R. Sellers,William R. Sellers,William R. Sellers,David Stokoe,Michael D. Prados,Timothy F. Cloughesy,Charles L. Sawyers,Paul S. Mischel +31 more
TL;DR: Coexpression of EGFRvIII and PTEN by glioblastoma cells is associated with responsiveness to EGFR kinase inhibitors, and effects of the molecular abnormalities in vitro are identified.
Journal ArticleDOI
Loss of PTEN facilitates HIF-1-mediated gene expression
Wayne Zundel,Cornelia Schindler,Daphne A. Haas-Kogan,Albert C. Koong,Fiona Kaper,Eunice Y. Chen,Alexander Gottschalk,Heather E. Ryan,Randall S. Johnson,Anne B. Jefferson,David Stokoe,Amato J. Giaccia +11 more
TL;DR: It is proposed that loss of PTEN during malignant progression contributes to tumor expansion through the deregulation of Akt activity and HIF-1-regulated gene expression.
Journal ArticleDOI
Long-Term Results for Children With High-Risk Neuroblastoma Treated on a Randomized Trial of Myeloablative Therapy Followed by 13-cis-Retinoic Acid: A Children's Oncology Group Study
Katherine K. Matthay,C. Patrick Reynolds,Robert C. Seeger,Hiroyuki Shimada,E. Stanton Adkins,Daphne A. Haas-Kogan,Robert B. Gerbing,Wendy B. London,Judith G. Villablanca +8 more
TL;DR: The long-term outcome of patients enrolled on CCG-3891, a high-risk neuroblastoma study in which patients were randomly assigned to undergo autologous purged bone marrow transplantation or to receive chemotherapy, and subsequent treatment with 13-cis-retinoic acid (Cis-RA), was assessed.
Journal ArticleDOI
Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC
TL;DR: A role for PTEN is suggested in regulating the activity of the PI 3-kinase pathway in malignant human cells.
Journal ArticleDOI
Epidermal Growth Factor Receptor, Protein Kinase B/Akt, and Glioma Response to Erlotinib
Daphne A. Haas-Kogan,Michael D. Prados,Tarik Tihan,David A. Eberhard,Nannette Jelluma,Nils D. Arvold,Rachel Baumber,Kathleen R. Lamborn,Ami Kapadia,Mary Malec,Mitchel S. Berger,David Stokoe +11 more
TL;DR: Among glioma patients, those with glioblastoma multiforme tumors who have high levels of EGFR expression and low levels of phosphorylated PKB/Akt had better response to erlotinib treatment than those with low levels.