D
Darius Lutter
Researcher at Leibniz Institute for Neurobiology
Publications - 4
Citations - 879
Darius Lutter is an academic researcher from Leibniz Institute for Neurobiology. The author has contributed to research in topics: Osmolyte & Cisplatin. The author has an hindex of 4, co-authored 4 publications receiving 687 citations. Previous affiliations of Darius Lutter include Free University of Berlin.
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Journal ArticleDOI
Identification of LRRC8 Heteromers as an Essential Component of the Volume-Regulated Anion Channel VRAC
Felizia K. Voss,Felizia K. Voss,Florian Ullrich,Florian Ullrich,Jonas Münch,Jonas Münch,Katina Lazarow,Darius Lutter,Darius Lutter,Nancy Mah,Miguel A. Andrade-Navarro,Jens Peter von Kries,Tobias Stauber,Thomas J. Jentsch,Thomas J. Jentsch +14 more
TL;DR: This work shows thatVRAC defines a class of anion channels, suggests that VRAC is identical to the volume-sensitive organic osmolyte/anion channel VSOAC, and explains the heterogeneity of native VRAC currents.
Journal ArticleDOI
Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs.
Rosa Planells-Cases,Darius Lutter,Charlotte Guyader,Nora M. Gerhards,Florian Ullrich,Deborah A Elger,Asli Kucukosmanoglu,Guotai Xu,Felizia K. Voss,S. Momsen Reincke,Tobias Stauber,Vincent A. Blomen,Daniel J. Vis,Lodewyk F. A. Wessels,Thijn R. Brummelkamp,Piet Borst,Sven Rottenberg,Sven Rottenberg,Thomas J. Jentsch,Thomas J. Jentsch +19 more
TL;DR: It is suggested that LRRC8D‐containing VRACs are crucial for cell volume regulation by an important organic osmolyte and may influence cisplatin/carboplatin responsiveness of tumors and play a dual role in the cellular drug response.
Journal ArticleDOI
Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels.
Darius Lutter,Florian Ullrich,Jennifer C. Lueck,Jennifer C. Lueck,Stefan Kempa,Thomas J. Jentsch +5 more
TL;DR: The ability of volume-regulated heteromeric VRAC channels to conduct organic compounds, including the neurotransmitters glutamate and GABA, depends on LRRC8D andLRRC8E subunits, and suggests new roles in transcellular signal transduction.
Journal ArticleDOI
VRAC: molecular identification as LRRC8 heteromers with differential functions
TL;DR: The remarkable journey which led to the molecular identification of VRAC is discussed, evidence for LRRC8 proteins forming the VRAC pore and their heteromeric assembly are discussed and first major insights on the role of LR RC8 proteins in cancer drug resistance and apoptosis and the role in cisplatin and taurine transport are summarized.