Felizia K. Voss

TL;DR: This work shows thatVRAC defines a class of anion channels, suggests that VRAC is identical to the volume-sensitive organic osmolyte/anion channel VSOAC, and explains the heterogeneity of native VRAC currents.

TL;DR: It is suggested that LRRC8D‐containing VRACs are crucial for cell volume regulation by an important organic osmolyte and may influence cisplatin/carboplatin responsiveness of tumors and play a dual role in the cellular drug response.

TL;DR: The remarkable journey which led to the molecular identification of VRAC is discussed, evidence for LRRC8 proteins forming the VRAC pore and their heteromeric assembly are discussed and first major insights on the role of LR RC8 proteins in cancer drug resistance and apoptosis and the role in cisplatin and taurine transport are summarized.

TL;DR: A highly conserved extracellular region preceding the second LRRC8 transmembrane domain as a major determinant of ICl,vol inactivation is uncovered and it is suggested that the C-terminal part of the firstextracellular loop not only determines VRAC inactivation but might also participate in forming its outer pore.

TL;DR: In this article , the authors investigated the mechanistic contribution of CAR in mediating responses to the common aeroallergen, House Dust Mite (HDM), and demonstrated that administration of HDM in mice lacking CAR in the respiratory epithelium leads to loss of peri-bronchial inflammatory cell infiltration, fewer goblet-cells and decreased pro-inflammatory cytokine release.