Vincent A. Blomen

TL;DR: A synthetic lethality network focused on the secretory pathway based exclusively on mutations was created and revealed a genetic cross-talk governing Golgi homeostasis, an additional subunit of the human oligosaccharyltransferase complex, and a phosphatidylinositol 4-kinase β adaptor hijacked by viruses.

TL;DR: It is shown here that chromatin loop size can be increased and that the duration with which cohesin embraces DNA determines the degree to which loops are enlarged, and that TADs reflect polyclonal collections of loops in the making.

TL;DR: Comprehensive forward genetic screens can be used to define the genetic architecture of a complex disease and point out genes defective in dystroglycanopathies.

TL;DR: The generation and characterization of iPSCs derived from human chronic myeloid leukemia cells are described and it is shown that, despite the presence of oncogenic mutations, these cells acquired pluripotency by the expression of 4 transcription factors and underwent differentiation into cell types derived of all 3 germ layers during teratoma formation.

TL;DR: It is suggested that LRRC8D‐containing VRACs are crucial for cell volume regulation by an important organic osmolyte and may influence cisplatin/carboplatin responsiveness of tumors and play a dual role in the cellular drug response.