Katina Lazarow

TL;DR: This work shows thatVRAC defines a class of anion channels, suggests that VRAC is identical to the volume-sensitive organic osmolyte/anion channel VSOAC, and explains the heterogeneity of native VRAC currents.

TL;DR: A genome-wide siRNA screen was used to molecularly identify the widely expressed acid-sensitive outwardly-rectifying anion channel PAORAC/ASOR, a feature essential for ASOR’s role in acid-induced cell death.

TL;DR: A structure-guided hybridization approach using two privileged substructures gave instant access to a new series of tankyrase inhibitors through the utilization of an appropriate linker between 1,2,4-triazole and benzimidazolone moieties, whereby a cyclobutyl linker displayed superior affinity compared to a cyclohexane and phenyl linkers.

TL;DR: A hitherto unrecognized signalosome comprising CDK18, an E3 ubiquitin ligase, STUB1 (CHIP), PKA and AQP2 that controls the localization and abundance of AQP 2 is revealed.