D
Darya Alizadeh
Researcher at City of Hope National Medical Center
Publications - 48
Citations - 3580
Darya Alizadeh is an academic researcher from City of Hope National Medical Center. The author has contributed to research in topics: Immune system & Chimeric antigen receptor. The author has an hindex of 22, co-authored 43 publications receiving 2540 citations. Previous affiliations of Darya Alizadeh include Beckman Research Institute & Brain Mapping Foundation.
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Journal ArticleDOI
Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy
Christine E. Brown,Darya Alizadeh,Renate Starr,Weng L,Wagner,Araceli Naranjo,Ostberg,Melvin Blanchard,Kilpatrick J,Simpson J,Kurien A,Saul J. Priceman,Xiuli Wang,Harshbarger Tl,Massimo D'Apuzzo,Ressler Ja,Michael C. Jensen,Michael E. Barish,Chen M,Jana Portnow,Stephen J. Forman,Behnam Badie +21 more
TL;DR: Recurrent multifocal glioblastoma patients received chimeric antigen receptor (CAR)-engineered T cells targeting the tumor-associated antigen interleukin-13 receptor alpha 2 (IL13Rα2) and regression of all intracranial and spinal tumors was observed, along with corresponding increases in levels of cytokines and immune cells in the cerebrospinal fluid.
Journal ArticleDOI
Doxorubicin Eliminates Myeloid-Derived Suppressor Cells and Enhances the Efficacy of Adoptive T-Cell Transfer in Breast Cancer
Darya Alizadeh,Malika Trad,Neale T. Hanke,Claire B. Larmonier,Nona Janikashvili,Bernard Bonnotte,Emmanuel Katsanis,Nicolas Larmonier +7 more
TL;DR: Results indicate that doxorubicin may be used not only as a direct cytotoxic drug against tumor cells, but also as a potent immunomodulatory agent that selectively impairs MDSC-induced immunosuppression, thereby fostering the efficacy of T-cell-based immunotherapy.
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IL15 Enhances CAR-T Cell Antitumor Activity by Reducing mTORC1 Activity and Preserving Their Stem Cell Memory Phenotype
Darya Alizadeh,Robyn A. Wong,Xin Yang,Dongrui Wang,Joseph R. Pecoraro,Cheng-Fu Kuo,Brenda Aguilar,Yue Qi,David K. Ann,Renate Starr,Ryan Urak,Xiuli Wang,Stephen J. Forman,Christine E. Brown +13 more
TL;DR: It is demonstrated that CAR-T cells expanded in IL15 (CAR-T/IL15) preserve a less-differentiated stem cell memory (Tscm) phenotype and improves their metabolic fitness, which results in superior in vivo antitumor activity, thus opening an avenue that may improve future adoptive T-cell therapies.
Journal ArticleDOI
Stat3 inhibition activates tumor macrophages and abrogates glioma growth in mice.
TL;DR: Inhibition of Stat3 function in tumor MG/MP may result in their activation and can potentially be used as an adjunct immunotherapy approach for gliomas, considering the proposed suppressive role of signal transducers and activators of transcription 3 in antitumor immunity.
Journal ArticleDOI
Carbon nanotubes enhance CpG uptake and potentiate antiglioma immunity.
Dongchang Zhao,Darya Alizadeh,Leying Zhang,Wei Liu,Omar Farrukh,Edwin R. Manuel,Don J. Diamond,Behnam Badie +7 more
TL;DR: In this article, carbon nanotubes (CNTs) were conjugated with CpG and evaluated in vitro and in mice bearing intracranial GL261 gliomas.