Dat P. Mao

TL;DR: The authors showed that activation of caspase-1 clears intracellular bacteria in vivo independently of IL-1β and IL-18 and establishes pyroptosis as an efficient mechanism of bacterial clearance by the innate immune system.

TL;DR: It is demonstrated that activation of caspase-1 clears intracellular bacteria in vivo independently of IL-1β and IL-18 and establishes pyroptosis as an efficient mechanism of bacterial clearance by the innate immune system.

TL;DR: The detection of a conserved component of the T3ss apparatus enables innate immune responses to virulent bacteria through a single pathway, a strategy that is divergent from that used by plants in which multiple NB-LRR proteins are used to detect T3SS effectors or their effects on cells as discussed by the authors.

TL;DR: It is demonstrated here that Pseudomonas aeruginosa activates caspase 1 and induces IL-1β secretion in infected macrophages and that Ipaf-dependent detection of cytosolic flagellin is a conserved mechanism by which macrophage detect the presence of pathogens that use T3SS.

TL;DR: Evidence is provided that suggests cytosolic L. monocytogenes activates caspase 1 in macrophages via multiple pathways, all of which detect the presence of bacteria within the cytosol, and that detection of flagellin promoted bacterial clearance in a murine infection model.