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Anasuya Sarkar
Researcher at Ohio State University
Publications - 34
Citations - 4229
Anasuya Sarkar is an academic researcher from Ohio State University. The author has contributed to research in topics: Caspase 1 & Inflammasome. The author has an hindex of 19, co-authored 32 publications receiving 3755 citations. Previous affiliations of Anasuya Sarkar include The Ohio State University Wexner Medical Center & Indian Institute of Chemical Biology.
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Journal ArticleDOI
Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
Edward A. Miao,Irina A. Leaf,Piper M. Treuting,Dat P. Mao,Monica Dors,Anasuya Sarkar,Sarah E. Warren,Sarah E. Warren,Mark D. Wewers,Alan Aderem +9 more
TL;DR: The authors showed that activation of caspase-1 clears intracellular bacteria in vivo independently of IL-1β and IL-18 and establishes pyroptosis as an efficient mechanism of bacterial clearance by the innate immune system.
Journal Article
Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria (111.33)
Edward A. Miao,Irina A. Leaf,Piper M. Treuting,Dat P. Mao,Anasuya Sarkar,Mark D. Wewers,Alan Aderem +6 more
TL;DR: It is demonstrated that activation of caspase-1 clears intracellular bacteria in vivo independently of IL-1β and IL-18 and establishes pyroptosis as an efficient mechanism of bacterial clearance by the innate immune system.
Journal ArticleDOI
Real-time PCR quantification of precursor and mature microRNA
Thomas D. Schmittgen,Eun Joo Lee,Jinmai Jiang,Anasuya Sarkar,Liuqing Yang,Terry S. Elton,Caifu Chen +6 more
TL;DR: By profiling over 200 precursor and mature miRNAs in HL60 cells induced to differentiate with 12-O-tetradecanoylphorbol-13-acetate, it was possible to identify mi RNAs who's processing is regulated during differentiation and become the gold standard of nucleic acid quantification.
Journal ArticleDOI
Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia
Mohamed Lamkanfi,Mohamed Lamkanfi,Mohamed Lamkanfi,Anasuya Sarkar,Lieselotte Vande Walle,Lieselotte Vande Walle,Alberto C. Vitari,Amal O. Amer,Mark D. Wewers,Kevin J. Tracey,Thirumala-Devi Kanneganti,Vishva M. Dixit +11 more
TL;DR: It is shown that mice lacking both IL-1β and IL-18 are normally susceptible to LPS-induced splenocyte apoptosis and endotoxic shock, and the existence of another caspase 1-dependent mediator of endotoxemia is indicated.
Journal ArticleDOI
Caspase-7 Activation by the Nlrc4/Ipaf Inflammasome Restricts Legionella pneumophila Infection
Anwari Akhter,Mikhail A. Gavrilin,Laura J. Frantz,Songcerae Washington,Cameron Ditty,Dominique H. Limoli,Colby Day,Anasuya Sarkar,Christie A. Newland,Jonathan P. Butchar,Clay B. Marsh,Mark D. Wewers,Susheela Tridandapani,Thirumala-Devi Kanneganti,Amal O. Amer +14 more
TL;DR: Using the intracellular pathogen L. pneumophila, it is shown that, upon infection of murine macrophages, caspase-7 was activated downstream of the Nlrc4 inflammasome and required casp enzyme-1 activation, and a novel biological role for caspasing-7 in host defense against an intrACEllular bacterium is presented.