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Irina A. Leaf
Researcher at Biogen Idec
Publications - 14
Citations - 3756
Irina A. Leaf is an academic researcher from Biogen Idec. The author has contributed to research in topics: Innate immune system & Caspase 1. The author has an hindex of 12, co-authored 14 publications receiving 3310 citations. Previous affiliations of Irina A. Leaf include University of Minnesota & Institute for Systems Biology.
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Journal ArticleDOI
Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
Edward A. Miao,Irina A. Leaf,Piper M. Treuting,Dat P. Mao,Monica Dors,Anasuya Sarkar,Sarah E. Warren,Sarah E. Warren,Mark D. Wewers,Alan Aderem +9 more
TL;DR: The authors showed that activation of caspase-1 clears intracellular bacteria in vivo independently of IL-1β and IL-18 and establishes pyroptosis as an efficient mechanism of bacterial clearance by the innate immune system.
Journal Article
Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria (111.33)
Edward A. Miao,Irina A. Leaf,Piper M. Treuting,Dat P. Mao,Anasuya Sarkar,Mark D. Wewers,Alan Aderem +6 more
TL;DR: It is demonstrated that activation of caspase-1 clears intracellular bacteria in vivo independently of IL-1β and IL-18 and establishes pyroptosis as an efficient mechanism of bacterial clearance by the innate immune system.
Journal ArticleDOI
Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome
Edward A. Miao,Dat P. Mao,Natalya Yudkovsky,Richard Bonneau,Cynthia G. Lorang,Sarah E. Warren,Sarah E. Warren,Irina A. Leaf,Alan Aderem +8 more
TL;DR: The detection of a conserved component of the T3ss apparatus enables innate immune responses to virulent bacteria through a single pathway, a strategy that is divergent from that used by plants in which multiple NB-LRR proteins are used to detect T3SS effectors or their effects on cells as discussed by the authors.
Journal ArticleDOI
Caspase-11 Protects Against Bacteria That Escape the Vacuole
Youssef Aachoui,Irina A. Leaf,Jon A. Hagar,Mary F. Fontana,Cristine G. Campos,Daniel E. Zak,Michael H. Tan,Peggy A. Cotter,Russell E. Vance,Alan Aderem,Edward A. Miao +10 more
TL;DR: It is reported that caspase-11 is required for innate immunity to cytosolic, but not vacuolar, bacteria and is critical for surviving exposure to ubiquitous environmental pathogens.
Journal ArticleDOI
Cutting Edge: Cytosolic Bacterial DNA Activates the Inflammasome via Aim2
Sarah E. Warren,Sarah E. Warren,Abraham M. Armstrong,M. Kristina Hamilton,Dat P. Mao,Irina A. Leaf,Edward A. Miao,Alan Aderem,Alan Aderem +8 more
TL;DR: In this paper, the authors used biochemical and genetic approaches to demonstrate that the third detector senses bacterial DNA and identify it as Aim2, a receptor that has previously been shown to detect viral DNA.