David A. Eisner

TL;DR: The factors that regulate and fine-tune the initiation and termination of release of Ca, including the role of Ca buffers, mitochondria, Ca leak, and regulation of diastolic [Ca2+]i are reviewed.

TL;DR: Voltage clamp experiments on isolated sheep Purkinje fibres showed an increase of the steady state outward membrane current, over the potential range −65 mV to −15 mV, in the presence of tetrodotoxin, considered to be the steadystate component of the fast sodium current (INa), resulting from the crossover of the activation and inactivation curves which govern the opening of the sodium channel.

TL;DR: This review illustrates how analysis of the control of calcium requires an integrated approach in which several systems are considered and predicts that, under some conditions, the above interactions can result in instability rather than ordered control of contractility.

TL;DR: Investigation of beat-to-beat alternation in the amplitude of the systolic Ca2+ transient (Ca2+ alternans) found that it was found that, in rat ventricular myocytes, stimulating with small (20 mV) depolarizing pulses produced alternans of the amplitudes of the Ca2- transient, which results from the steep dependence on SR Ca2+.

TL;DR: In this article, the authors show that sarcoplasmic reticulum (SR) Ca2+ content reflects the balance between Ca2 uptake (via SERCA) and Ca2 efflux via ryanodine receptor (RyR).