M
Mary E. Díaz
Researcher at University of Edinburgh
Publications - 44
Citations - 3057
Mary E. Díaz is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Ryanodine receptor & Calcium. The author has an hindex of 28, co-authored 44 publications receiving 2902 citations. Previous affiliations of Mary E. Díaz include University of Manchester & University of Liverpool.
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Journal ArticleDOI
Integrative Analysis of Calcium Cycling in Cardiac Muscle
TL;DR: This review illustrates how analysis of the control of calcium requires an integrated approach in which several systems are considered and predicts that, under some conditions, the above interactions can result in instability rather than ordered control of contractility.
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Sarcoplasmic Reticulum Calcium Content Fluctuation Is the Key to Cardiac Alternans
TL;DR: Investigation of beat-to-beat alternation in the amplitude of the systolic Ca2+ transient (Ca2+ alternans) found that it was found that, in rat ventricular myocytes, stimulating with small (20 mV) depolarizing pulses produced alternans of the amplitudes of the Ca2- transient, which results from the steep dependence on SR Ca2+.
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Measurement of sarcoplasmic reticulum Ca2+ content and sarcolemmal Ca2+ fluxes in isolated rat ventricular myocytes during spontaneous Ca2+ release.
TL;DR: It is concluded that spontaneous release of calcium, although potentially arrhythmogenic, is an effective way to activate Ca2+ efflux in overloaded conditions and minimizes any increase of diastolic tension.
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The control of Ca release from the cardiac sarcoplasmic reticulum: regulation versus autoregulation
TL;DR: The mechanism and regulation of Ca release from the cardiac sarcoplasmic reticulum is discussed, and it is shown that, due to compensatory changes of s.r. Ca, modifiers of the RyR only produce transient effects on systolic Ca.
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Modulation of CICR has no maintained effect on systolic Ca2+: simultaneous measurements of sarcoplasmic reticulum and sarcolemmal Ca2+ fluxes in rat ventricular myocytes.
TL;DR: The results confirm that modulation of the ryanodine receptor has no maintained effect on systolic Ca2+ and show the interdependence of SR Ca2- content, cytoplasmic Ca 2+ buffering and sarcolemmal Ca2+.