Integrative Analysis of Calcium Cycling in Cardiac Muscle
Reads0
Chats0
TLDR
This review illustrates how analysis of the control of calcium requires an integrated approach in which several systems are considered and predicts that, under some conditions, the above interactions can result in instability rather than ordered control of contractility.Abstract:
The control of intracellular calcium is central to regulation of contractile force in cardiac muscle. This review illustrates how analysis of the control of calcium requires an integrated approach in which several systems are considered. Thus, the calcium content of the sarcoplasmic reticulum (SR) is a major determinant of the amount of Ca(2+) released from the SR and the amplitude of the Ca(2+) transient. The amplitude of the transient, in turn, controls Ca(2+) fluxes across the sarcolemma and thence SR content. This control of SR content influences the response to maneuvers that modify, for example, the properties of the SR Ca(2+) release channel or ryanodine receptor. Specifically, modulation of the open probability of the ryanodine receptor produces only transient effects on the Ca(2+) transient as a result of changes of SR content. These interactions between various Ca(2+) fluxes are modified by the Ca(2+) buffering properties of the cell. Finally, we predict that, under some conditions, the above interactions can result in instability (such as alternans) rather than ordered control of contractility.read more
Citations
More filters
Journal ArticleDOI
Cardiac excitation–contraction coupling
TL;DR: Of the ions involved in the intricate workings of the heart, calcium is considered perhaps the most important and spatial microdomains within the cell are important in localizing the molecular players that orchestrate cardiac function.
Journal ArticleDOI
Mechanisms Underlying Acute Protection From Cardiac Ischemia-Reperfusion Injury
TL;DR: Preconditioning activates a number of signaling pathways that reduce Ca(2+) overload and reduce activation of the mitochondrial permeability transition pore, and reducing ROS have both been reported to reduce ischemic injury.
Journal ArticleDOI
Genesis and Regulation of the Heart Automaticity
Matteo E. Mangoni,Joël Nargeot +1 more
TL;DR: Evidence on the functional role of different families of ion channels in cardiac pacemaking is discussed and recent results obtained on genetically engineered mouse strains displaying dysfunction in heart automaticity are reviewed.
Journal ArticleDOI
Calcium and Excitation-Contraction Coupling in the Heart.
TL;DR: The factors that regulate and fine-tune the initiation and termination of release of Ca, including the role of Ca buffers, mitochondria, Ca leak, and regulation of diastolic [Ca2+]i are reviewed.
Journal ArticleDOI
Calcium cycling in congestive heart failure
Gerd Hasenfuss,Burkert Pieske +1 more
TL;DR: Calcium Cycling in Congestive Heart Failure is described, which shows an inverse relationship between heart failure and serum calcium levels, and the number ofocytes in the blood stream decreases with age.
References
More filters
Journal ArticleDOI
PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.
Steven O. Marx,Steven Reiken,Yuji Hisamatsu,Thotalla Jayaraman,Daniel Burkhoff,Nora Rosemblit,Andrew R. Marks +6 more
TL;DR: It is shown that protein kinase A (PKA) phosphorylation of RyR2 dissociates FKBP12.6 and regulates the channel open probability (Po), resulting in defective channel function due to increased sensitivity to Ca2+-induced activation.
Journal ArticleDOI
Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle
TL;DR: The calcium spark is the consequence of elementary events underlying excitation-contraction coupling and provides an explanation for both spontaneous and triggered changes in the intracellular calcium concentration in the mammalian heart.
Journal ArticleDOI
Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum
TL;DR: The hypothesis of a Ca2 +-induced Ca2+ release (CICR) from the sarcoplasmic reticulum (SR) is supported by experiments done in skinned cardiac cells (sarcolemma removed by microdissection).
Journal ArticleDOI
Ryanodine Receptor/Ca2+ Release Channels and Their Regulation by Endogenous Effectors
TL;DR: Foot structures have been termed feet and are now commonly known as ryanodine receptor/Ca2+ release channels because of the presence of an intrinsic ci+ channel activity within the feet structures, and their ability to bind the plant.
Journal ArticleDOI
Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein.
Anne-Marie B. Brillantes,Karol Ondrias,Karol Ondrias,Andrew Scott,Andrew Scott,Evgeny Kobrinsky,Evgeny Kobrinsky,Elena Ondriasova,Maria C. Moschella,Maria C. Moschella,Thottala Jayaraman,Thottala Jayaraman,Mark Landers,Mark Landers,Barbara E. Ehrlich,Barbara E. Ehrlich,Andrew R. Marks,Andrew R. Marks +17 more
TL;DR: These results provide the first natural cellular function for FKBP12, and establish that the functional Ca2+ release channel complex includes FK BP12.