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David A. Gewirtz
Researcher at Virginia Commonwealth University
Publications - 182
Citations - 22854
David A. Gewirtz is an academic researcher from Virginia Commonwealth University. The author has contributed to research in topics: Autophagy & Cancer. The author has an hindex of 47, co-authored 162 publications receiving 18755 citations. Previous affiliations of David A. Gewirtz include VCU Medical Center.
Papers
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Journal ArticleDOI
Stilbene 5c, a microtubule poison with vascular disrupting properties that induces multiple modes of growth arrest and cell death
Moureq R. Alotaibi,B. Asnake,Xu Di,Matthew J. Beckman,David Durrant,Daniele Simoni,Riccardo Baruchello,Ruey-min Lee,Edward L. Schwartz,David A. Gewirtz +9 more
TL;DR: This work indicates that stilbene 5c could potentially be effective against melanoma and colon cancer through the promotion of multiple modes of growth arrest and cell death coupled with anti-angiogenic and antivascular actions.
Journal ArticleDOI
Fluvastatin Induces Apoptosis in Primary and Transformed Mast Cells.
Patrick A Paez,E. Motunrayo Kolawole,Marcela T. Taruselli,Siddarth Ajith,Jordan M. Dailey,Sydney A. Kee,Tamara T. Haque,Brian O. Barnstein,Jamie Josephine Avila McLeod,Heather L. Caslin,Kasalina N. Kiwanuka,Yoshihiro Fukuoka,Quang T. Le,Lawrence B. Schwartz,David B. Straus,David A. Gewirtz,Rebecca K. Martin,John J. Ryan +17 more
TL;DR: Fluvastatin, a statin drug used to lower cholesterol, induces apoptosis in primary and transformed mast cells by antagonizing protein isoprenylation, effectively inhibiting stem cell factor (SCF)-induced survival signals, providing insight into the mechanisms of mast cell survival.
Journal Article
Apoptosis as the predominant tumor cell response to chemotherapy and irradiation: a case of TUNEL vision?
David A. Gewirtz,Lynne W. Elmore +1 more
Journal ArticleDOI
Rb dephosphorylation and suppression of E2F activity in human breast tumor cells exposed to a pharmacological concentration of estradiol.
David A. Gewirtz,Yong-Mei Di,Joyce K. Randolph,Pramod T. Jain,Kristoffer Valerie,Sharon Bullock,Niharika Nath,Srikumar Chellappan +7 more
TL;DR: In addition to the lack of caspase-3 in MCF-7 cells, the absence of apoptosis could be related, at least in part, to the fact that estradiol promotes a rapid reduction in levels of the E2F-1 and Myc proteins.
Patent
Pharmaco-gene delivery in human breast cancer cells
Pramod Jain,David A. Gewirtz +1 more
TL;DR: Estradiol facilitates non-viral gene delivery to breast tumor cells and the effect is dose dependent, and is independent of the gene construct, temperature, and tumor cell line.