David A. Gewirtz

TL;DR: Studies in the laboratory support the premise that radiosensitization of breast tumor cells by vitamin D or vitamin D analogs is mediated through autophagy, and promotion of autophagic cell death by a vitaminD analog in irradiated breast tumor Cells delays and attenuates the proliferative recovery that may be a preclinical indicator of disease recurrence.

TL;DR: The studies suggest that the effect of EB 1089 treatment on the radiation response is related in part to enhanced promotion of autophagic cell death and in large part to interference with the proliferative recovery that occurs with radiation alone in p53 wild-type breast tumor cells.

TL;DR: 5 clinical phase I trials combining hydroxychloroquine with vorinostat, temsirolimus, temozolomide, or bortezomib should provide guidance in the planning and design of future trials to directly determine whether the strategy of autophagy inhibition could prove useful in the treatment of various malignancies.

TL;DR: The down-regulation of c-myc expression may reflect perturbations in regulatory processes contributing to growth arrest in MCF-7 cells exposed to topoisomerase II inhibitors.

TL;DR: These studies suggest that accelerated senescence induced by Adriamycin is similar in cells with wild type p53 and in cells lacking functional p53 with regard to the upregulation of p21(waf1/cip1), down regulation of cdc2 and the involvement of reactive oxygen species.