David A. Gewirtz

TL;DR: A systematic study of XRT-induced cardiomyopathy in the mouse and the incidence and pathophysiology remains poorly described due to a lack of prospective data and a latency period that exceeds the follow-up duration of most clinical studies.

TL;DR: Transport studies indicate reduced intracellular accumulation and retention of daunorubicin in the K562-R cells as compared to the parent cell line, and suggest the presence of distinct cellular pools composed of both rapidly and slowly exchanging drug, with the rapidly exchanging pool being more pronounced in the resistant line.

TL;DR: Data indicate that EB 1089 (and 1alpha, 25 dihydroxycholecalciferol or its analogs) could selectively enhance breast tumor cell sensitivity to radiation through the promotion of cell death, in part through the generation of ceramide and the suppression of polo-like kinase.

TL;DR: Analysis of the influence of tamoxifen on growth inhibition by doxorubicin in the MCF-7 breast tumor cell line in vitro provided clear evidence of antagonism between these agents.

TL;DR: Clonogenic survival assays showed that the adenovirus expressing the truncated XRCC4 protein sensitizes MDA-MB-231 breast tumor cells to ionizing radiation, presumably through interference with the functional activity of ligase IV, leading to inhibition of the final ligation step in end joining.