D
David Bareford
Researcher at Russells Hall Hospital
Publications - 41
Citations - 3901
David Bareford is an academic researcher from Russells Hall Hospital. The author has contributed to research in topics: Essential thrombocythemia & Myelofibrosis. The author has an hindex of 20, co-authored 41 publications receiving 3700 citations. Previous affiliations of David Bareford include Belfast City Hospital & Wellcome Trust Sanger Institute.
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Journal ArticleDOI
Hydroxyurea Compared with Anagrelide in High-Risk Essential Thrombocythemia
Claire N. Harrison,Peter J. Campbell,Georgina Buck,Keith Wheatley,Clare L. East,David Bareford,Bridget S. Wilkins,van der Walt Jd,John T. Reilly,Andrew Grigg,Paula A. Revell,Woodcock Be,Anthony R. Green +12 more
TL;DR: Hydxyurea plus low-dose aspirin is superior to anagrelideplus low- dose aspirin for patients with essential thrombocythemia at high risk for vascular events.
Journal ArticleDOI
Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: a prospective study
Peter J. Campbell,Linda M. Scott,Georgina Buck,Keith Wheatley,Clare L. East,Joanne T Marsden,Audrey Duffy,Elaine M. Boyd,Anthony J. Bench,Michael A. Scott,George S. Vassiliou,Donald Milligan,Steve Smith,Wendy N. Erber,David Bareford,Bridget S. Wilkins,John T. Reilly,Claire N. Harrison,Anthony R. Green,Anthony R. Green +19 more
TL;DR: The results suggest that JAK2 V617F-positive essential thrombocythaemia and polycythaemia vera form a biological continuum, with the degree of erythrocytosis determined by physiological or genetic modifiers.
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MPL mutations in myeloproliferative disorders: analysis of the PT-1 cohort.
Philip A. Beer,Peter J. Campbell,Linda M. Scott,Anthony J. Bench,Wendy N. Erber,David Bareford,Bridget S. Wilkins,John T. Reilly,Hans Carl Hasselbalch,Richard Bowman,Keith Wheatley,Georgina Buck,Claire N. Harrison,Anthony R. Green +13 more
TL;DR: It is demonstrated that MPL mutations outside exon 10 are uncommon in platelet cDNA and 4 different exon10 mutations in granulocyte DNA from a retrospective cohort of 200 patients with ET or IMF are identified.
Journal ArticleDOI
Guidelines for the diagnosis, investigation and management of polycythaemia/erythrocytosis
Mary Frances McMullin,David Bareford,Peter J. Campbell,Anthony R. Green,Claire N. Harrison,Beverley J. Hunt,David Oscier,M. I. Polkey,John T. Reilly,Eric Rosenthal,Kate Ryan,Thomas C. Pearson,Bridget S. Wilkins +12 more
TL;DR: Since only the red cell lineage is involved, the term erythrocytosis has more validity and will be used throughout this article, and polycythaemia will be retained in relation to the clonal disorder, polycytaemia vera (PV), in which three cell lineages are involved.
Journal ArticleDOI
Two routes to leukemic transformation after a JAK2 mutation–positive myeloproliferative neoplasm
Philip A. Beer,François Delhommeau,Jean-Pierre Lecouedic,Mark A. Dawson,Edwin Chen,David Bareford,Rajko Kusec,Mary Frances McMullin,Claire N. Harrison,Alessandro M. Vannucchi,William Vainchenker,Anthony R. Green +11 more
TL;DR: Results indicate that different pathogenetic mechanisms underlie transformation to JAK2 wild-type and JAK1-mutant AML, show that TET2 mutations may be present in a clone distinct from that harboring aJAK2 mutation, and emphasize the clonal heterogeneity of the MPNs.