David C. Dale

TL;DR: In this article , the authors conducted a multinational, retrospective review of clinicopathologic features of patients with established WHIMs (n=20) or germline CXCR4 variants considered likely pathogenic or of uncertain significance, including 14 BM specimens and 10 PB smears.

TL;DR: A survey of the activities and attitudes of general medic ine groups practicing in 22 large multispecialty clinics across the United States points out the need to refine the authors' training programs and to attract good students to them and suggests that longitudinal care of patients with significant illnesses will more frequent ly become the domain of well-trained generalists.

TL;DR: In this issue of Blood, Kawai and colleagues report careful and detailed studies on the effects of expression of mutant CXCR4 in mobilized human CD 34+ cells (peripheral blood progenitor cells or PBSCs) studied in ex vivo cultures and with engraftment into NOD/

TL;DR: Makaryan et al. as mentioned in this paper showed that cell permeable inhibitors of neutrophil elastase (NE), especially an inhibitor developed my Merck, MK-0339, can correct the defect in cell survival and maturation in cellular models of HL60 cells and induced pluripotent stem cells.

TL;DR: In this paper, methods and compositions for treating or preventing WHIM syndrome and certain other disorders or conditions with a certain CXCR4 antagonist were described and evaluated. But none of the methods were described in detail.