D
David C. Dale
Researcher at University of Washington
Publications - 419
Citations - 26111
David C. Dale is an academic researcher from University of Washington. The author has contributed to research in topics: Neutropenia & Congenital Neutropenia. The author has an hindex of 85, co-authored 406 publications receiving 24613 citations. Previous affiliations of David C. Dale include National Institutes of Health & Fred Hutchinson Cancer Research Center.
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Journal ArticleDOI
An Adult Dog with Cyclic Neutropenia Treated by Lentivirus- Mediated Delivery of Granulocyte Colony-Stimulating Factor
Ofer Yanay,Margaret Brzezinski,Jeffrey Christensen,Denny Liggitt,David C. Dale,William R. A. Osborne +5 more
TL;DR: These studies show that an adult animal is responsive long-term to lentivirus-mediated G-CSF delivery, suggesting this approach may be applied for treatment of adult patients with cyclic and other neutropenias.
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Guidelines for pediatric management of severe chronic neutropenia
David C. Dale,Laurence A. Boxer +1 more
TL;DR: Recommendations about several controversial issues that differ somewhat from the recommendations and statements for the SCNIR are provided, including Shwachman–Diamond syndrome may be at greater risk of leukemic transformation and therefore advises ‘‘on-demand’’ G-CSF.
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Cost of Hospitalization in Patients with Cancer and Febrile Neutropenia and Impact of Comorbid Conditions
TL;DR: Hospitalization costs increased in patients with major comorbidities with the highest mean costs for venous thromboembolism, cerebrovascular disease, and hepatic disease with mean lengths of stay of 15.6, 14.8, and 13.2 days, respectively, regardless of tumor type.
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Changing Patterns of Chemotherapy Delivery and Supportive Care for Aggressive B-Cell Non-Hodgkin's Lymphoma
TL;DR: This study showed that primary prophylactic use of colony-stimulating factors (CSF) starting with the first cycle of chemotherapy was associated with a reduced incidence of febrile neutropenia (FN) and was an independent predictor of RDI ≥ 85%.
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Emerging role of apoptosis in the pathogenesis of severe neutropenia.
TL;DR: The controlled deletion and removal of unwanted cells is of fundamental importance in normal hematopoiesis, particularly for cells of the neutrophil lineage with the high turnover rate of these cells.