D
David C. Hill-Eubanks
Researcher at University of Vermont
Publications - 57
Citations - 3998
David C. Hill-Eubanks is an academic researcher from University of Vermont. The author has contributed to research in topics: Vasodilation & NFAT. The author has an hindex of 31, co-authored 52 publications receiving 3252 citations.
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Journal ArticleDOI
Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function
Swapnil K. Sonkusare,Adrian D. Bonev,Jonathan Ledoux,Jonathan Ledoux,Wolfgang Liedtke,Michael I. Kotlikoff,Thomas J. Heppner,David C. Hill-Eubanks,Mark T. Nelson,Mark T. Nelson +9 more
TL;DR: Results support the concept that Ca2+ influx through single TRPV4 channels is leveraged by the amplifier effect of cooperative channel gating and the high Ca2- sensitivity of IK and SK channels to cause vasodilation.
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Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow
Thomas A Longden,Fabrice Dabertrand,Masayo Koide,Albert L. Gonzales,Nathan R. Tykocki,Joseph E. Brayden,David C. Hill-Eubanks,Mark T. Nelson,Mark T. Nelson +8 more
TL;DR: The results establish brain capillaries as an active sensory web that converts changes in external K+ into rapid, 'inside-out' electrical signaling to direct blood flow to active brain regions.
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Calcium Signaling in Smooth Muscle
TL;DR: Changes in intracellular Ca(2+) are central to the function of smooth muscle, which lines the walls of all hollow organs, and these changes take a variety of forms, from sustained, cell-wide increases to temporally varying, localized changes.
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Association of the factor VIII light chain with von Willebrand factor.
TL;DR: These data are consistent with the hypothesis that a critical step in blood coagulation is the release of all regions of fVIII from vWF following a single proteolytic cleavage of fVIIILC.
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TRPV4 channels stimulate Ca2+-induced Ca2+ release in astrocytic endfeet and amplify neurovascular coupling responses
TL;DR: A dynamic synergy between TRPV4 channels and IP3Rs in astrocyte endfeet is identified and demonstrated and it is demonstrated that TRPv4 channels are engaged in and contribute to neurovascular coupling.