D
David C. Mauchley
Researcher at University of Alabama at Birmingham
Publications - 32
Citations - 494
David C. Mauchley is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Transplantation & Xenotransplantation. The author has an hindex of 10, co-authored 30 publications receiving 374 citations. Previous affiliations of David C. Mauchley include UAB Hospital & Children's of Alabama.
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Journal ArticleDOI
Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: Role of Smad1 and extracellular signal-regulated kinase 1/2
Xiaoping Yang,Xianzhong Meng,Xin Su,David C. Mauchley,Lihua Ao,Joseph C. Cleveland,David A. Fullerton +6 more
TL;DR: Interstitial cells of stenotic human aortic valves are characterized by increased bone morphogenic protein 2 levels, and the Smad1 pathway plays a role in regulating the expression of both Runx2 and osteopontin induced by bone morphogen protein 2.
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Clinical utility and cost-effectiveness of routine preoperative computed tomography scanning in patients with colon cancer.
David C. Mauchley,Dana Christian Lynge,Lorrie A. Langdale,Matthias Stelzner,Charles Mock,Kevin G. Billingsley +5 more
TL;DR: Routine preoperative CT scanning definitively alters treatment in a small number of cases and is cost-effective in colon cancer patients, and saved the institution $24,018 over 6 years.
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The Case for Cardiac Xenotransplantation in Neonates: Is Now the Time to Reconsider Xenotransplantation for Hypoplastic Left Heart Syndrome?
David C. Cleveland,C. Adam Banks,Hidetaka Hara,Waldemar F. Carlo,David C. Mauchley,David K. C. Cooper +5 more
TL;DR: It is proposed that now is the time to consider devoting research to advance the potential clinical application of cardiac xenotransplantation as a treatment option for patients with HLHS.
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Knockdown of secretory phospholipase A2 IIa reduces lung cancer growth in vitro and in vivo
Jessica A. Yu,David C. Mauchley,Howard Li,Xianzhong Meng,Raphael A. Nemenoff,David A. Fullerton,Michael J. Weyant +6 more
TL;DR: Knockdown of sPLA2 IIa suppresses lung cancer growth in part by attenuating NF-κB activity and justifies further investigation into the cellular mechanisms of s PLA2 in lung cancer and its potential role as a therapeutic target.
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Evaluation of Cardiothoracic Surgery Residency and Fellowship Program Websites.
Vanessa M. Miller,Luz A. Padilla,Alissa C. Schuh,David C. Mauchley,David C. Cleveland,Zviadi Aburjania,Robert J. Dabal +6 more
TL;DR: Improving cardiothoracic website accessibility and content may have implications for attracting the most competitive applicants while limiting the financial and scheduling demands associated with the interview process.