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David C. McLeod
Researcher at Southern Methodist University
Publications - 7
Citations - 77
David C. McLeod is an academic researcher from Southern Methodist University. The author has contributed to research in topics: Reversible addition−fragmentation chain-transfer polymerization & Chain transfer. The author has an hindex of 5, co-authored 6 publications receiving 63 citations. Previous affiliations of David C. McLeod include Heidelberg University (Ohio) & Methodist University.
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Journal ArticleDOI
β-Lactamase inhibition by 7-alkylidenecephalosporin sulfones: allylic transposition and formation of an unprecedented stabilized acyl-enzyme.
Elizabeth A. Rodkey,David C. McLeod,Christopher R. Bethel,Kerri M. Smith,Yan Xu,Weirui Chai,Tao Che,Paul R. Carey,Robert A. Bonomo,Focco van den Akker,John D. Buynak +10 more
TL;DR: Two mechanistic schemes are proposed, differing in whether, subsequent to acylation of the active site serine and opening of the β-lactam, the resultant dihydrothiazine fragments on its own or is assisted by an adjacent nucleophilic atom, in the form of the carbonyl oxygen of the C7 tert-butyloxycarbonyl group.
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Atom transfer radical polymerization of an epoxide‐containing monomer, 4‐vinylphenyloxirane, employing low concentration of catalyst: synthesis of linear and star‐shaped macromolecules
TL;DR: In this paper, 4-Vinylphenyloxirane (4VPO) was homopolymerized under initiators for continuous activator regeneration atom transfer radical polymerization (ATRP) conditions using diethyl 2-bromo-2-methylmalonate, ethyl 2bromoisobyrate, as well as tri-, tetra-and hexafunctional 2Bromisobutyrates as the initiators to yield well-defined linear and star-shaped epoxide-containing homopolymers.
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Well‐defined epoxide‐containing styrenic polymers and their functionalization with alcohols
TL;DR: In this article, the acid-catalyzed ring-opening of aryl-substituted epoxides by alcohols to form β-hydroxy ether products was investigated.
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4-Vinylphenyl Glycidyl Ether: Synthesis, RAFT Polymerization, and Postpolymerization Modifications with Alcohols
TL;DR: In this article, 4-Vinylphenyl glycidyl ether (4VPGE), an epoxide-containing styrenic monomer, was synthesized and then polymerized in a controlled fashion under reversible addition-fragmentation chain-transfer (RAFT) polymerization conditions using butyl 1-phenylethyl trithiocarbonate as the chain transfer agent.
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Reversible Deactivation Radical Polymerization of Monomers Containing Activated Aziridine Groups.
TL;DR: PolyVPA produced under nitroxide-mediated polymerization (NMP) conditions had narrow molecular weight distribution at low to moderate conversions of monomer, but branched and eventually cross-linked polymers were formed at higher conversions due to ring-opening reactions of the aziridine groups.