D
David Cowburn
Researcher at Albert Einstein College of Medicine
Publications - 223
Citations - 12923
David Cowburn is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Nuclear magnetic resonance spectroscopy & SH3 domain. The author has an hindex of 55, co-authored 218 publications receiving 12386 citations. Previous affiliations of David Cowburn include National Institutes of Health & VU University Amsterdam.
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Journal ArticleDOI
Accurate quantitation of protein expression and site-specific phosphorylation
TL;DR: The present method is general and affords a quantitative description of cellular differences at the level of protein expression and modification, thus providing information that is critical to the understanding of complex biological phenomena.
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Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions.
Ke Shuai,Curt M. Horvath,Linda H.Tsai Huang,Sajjad A. Qureshi,David Cowburn,James E. Darnell +5 more
TL;DR: It is reported here that the inactive Stat91 in the cytoplasm of untreated cells is a monomer and that upon IFN-gamma-induced phosphorylation it forms a stable homodimer.
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Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: Crystal structures of the complexed and peptide-free forms
TL;DR: The crystal structure of the Src SH2 domain complexed with a high affinity 11-residue phosphopeptide has been determined at 2.7 A resolution by X-ray diffraction, and comparison with the structure with the high affinity complex reveals only localized and relatively small changes.
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Crystal-structure of the phosphotyrosine recognition domain sh2 of v-src complexed with tyrosine-phosphorylated peptides
Gabriel Waksman,Dorothea Kominos,Scott C. Robertson,Scott C. Robertson,Nalin Pant,David Baltimore,Raymond B. Birge,David Cowburn,Hidesaburo Hanafusa,Bruce J. Mayer,Michael Overduin,Marilyn D. Resh,Marilyn D. Resh,Carlos B. Rios,Lauren Silverman,Lauren Silverman,John Kuriyan,John Kuriyan +17 more
TL;DR: Three-dimensional structures of complexes of the SH2 domain of the v-src oncogene product with two phosphotyrosyl peptides have been determined by X-ray crystallography at resolutions of 1.5 and 2.0 Å.
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Modular peptide recognition domains in eukaryotic signaling.
John Kuriyan,David Cowburn +1 more
TL;DR: The structural bases of the specificities of recognition by SH2, SH3, and PTB domains have been elucidated by X-ray crystallography and NMR, and the mechanism of cooperative interactions between these domains is discussed.