J
James E. Darnell
Researcher at Rockefeller University
Publications - 288
Citations - 69767
James E. Darnell is an academic researcher from Rockefeller University. The author has contributed to research in topics: RNA & Transcription (biology). The author has an hindex of 123, co-authored 287 publications receiving 67038 citations. Previous affiliations of James E. Darnell include National Institutes of Health & Columbia University.
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Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
TL;DR: A previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that phosphorylate substrate proteins called STATs (signal transducers and activators of transcription).
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STATs and Gene Regulation
TL;DR: The discovery of a STAT in Drosophila, and most recently in Dictyostelium discoideum, implies an ancient evolutionary origin for this dual-function set of proteins.
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Stat3 as an Oncogene
Jacqueline Bromberg,Melissa H. Wrzeszczynska,Geeta Devgan,Yanxiang Zhao,Richard G. Pestell,Chris Albanese,James E. Darnell +6 more
TL;DR: Substitution of two cysteine residues within the C-terminal loop of the SH2 domain of Stat3 produces a molecule that dimerizes spontaneously, binds to DNA, and activates transcription.
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STATs: transcriptional control and biological impact
David E. Levy,James E. Darnell +1 more
TL;DR: The signal transducer and activator of transcription (STAT) proteins are among the most well studied of the latent cytoplasmic signal-dependent transcription-factor pathways.
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Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation.
TL;DR: It is shown that gene activation by Stat1 and Stat3, which obligatorily require tyrosine phosphorylation to become active, also depends for maximal activation on one or more of the many serine kinases.