Michael Eby

TL;DR: A novel ubiquitin ligase domain is defined and two sequential mechanisms by which A20 downregulates NF-κB signalling are identified, both of which participate in mediating a distinct regulatory effect.

TL;DR: The adaptor protein Bcl10 promotes activation of NF-κB transcription factors through paracaspase- and UBC13-dependent ubiquitination of NEMO.

TL;DR: The data identify DUBA as a negative regulator of innate immune responses as well as a discrete ubiquitin interaction motif within DUBA for efficient deubiquitination of TRAF3 and optimal suppression of IFN-I.

TL;DR: The presence of frequent mutations in p85alpha in colon cancer are shown, a majority of which occurs in the inter-Src homology-2 (iSH2) domain, to promote cell survival, AKT activation, anchorage-independent cell growth, and oncogenesis in a p110-dependent manner.

TL;DR: Inducible short-hairpin RNA xenograft models are developed to examine the in vivo efficacy of inhibiting oncogenic BRAF and show that tumor regression resulting from BRAF suppression is inducible, reversible, and tightly regulated in these models.