P
Patrick Dowd
Researcher at Genentech
Publications - 19
Citations - 4359
Patrick Dowd is an academic researcher from Genentech. The author has contributed to research in topics: Gene & Receptor. The author has an hindex of 15, co-authored 19 publications receiving 4202 citations. Previous affiliations of Patrick Dowd include University of California, Berkeley & Nemours Foundation.
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Journal ArticleDOI
Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer
Robert M. Pitti,Scot A. Marsters,David A. Lawrence,Margaret Ann Roy,Frank C. Kischkel,Patrick Dowd,Arthur J Huang,Christopher J. Donahue,Steven Sherwood,Daryl T. Baldwin,Paul J. Godowski,William I. Wood,Austin L. Gurney,Kenneth J. Hillan,Robert L. Cohen,Audrey Goddard,David Botstein,Avi Ashkenazi +17 more
TL;DR: Certain tumours may escape FasL-dependent immune-cytotoxic attack by expressing a decoy receptor that blocks FasL, which was amplified in about half of 35 primary lung and colon tumours studied and DcR3 messenger RNA was expressed in malignant tissue.
Journal ArticleDOI
The ubiquitin ligase COP1 is a critical negative regulator of p53.
David Dornan,Ingrid E. Wertz,Ingrid E. Wertz,Harumi Shimizu,David Arnott,Gretchen Frantz,Patrick Dowd,Karen O'Rourke,Hartmut Koeppen,Vishva M. Dixit +9 more
TL;DR: COP1 is a critical negative regulator of p53 and represents a new pathway for maintaining p53 at low levels in unstressed cells and is identified as a p53-inducible gene.
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Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families
Lori Friedman,Elizabeth A. Ostermeyer,Csilla Szabo,Patrick Dowd,Eric D. Lynch,Sarah Rowell,Mary Claire King +6 more
TL;DR: Genetic evidence supporting the identity of the candidate gene for BRCA1 through the characterization of germline mutations in 63 breast cancer patients and 10 ovarian cancer patients in ten families with cancer linked to chromosome 17q21 is provided.
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The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment
Hilary Clark,Austin L. Gurney,Evangeline Abaya,Kevin P. Baker,Daryl T. Baldwin,Jennifer Brush,Jian Chen,Bernard Chow,Clarissa Chui,Craig Crowley,Bridget Currell,Bethanne Deuel,Patrick Dowd,Dan L. Eaton,Jessica Foster,Christopher Grimaldi,Qimin Gu,Philip E. Hass,Sherry Heldens,Arthur J Huang,Hok Seon Kim,Laura Klimowski,Yisheng Jin,Stephanie Johnson,James Lee,Lhney Lewis,Dongzhou Liao,Melanie R. Mark,Edward P. Robbie,Celina Sanchez,Jill Schoenfeld,Somasekar Seshagiri,Laura Simmons,Jennifer Singh,Victoria Smith,Jeremy Stinson,Alicia Vagts,Richard Vandlen,Colin K. Watanabe,David Wieand,Kathryn Woods,Ming-Hong Xie,Daniel G. Yansura,Sothy Yi,Guoying Yu,Jean Yuan,Min Zhang,Zemin Zhang,Audrey Goddard,William I. Wood,Paul J. Godowski +50 more
TL;DR: The SPDI collection should facilitate efforts to better understand intercellular communication, may lead to new understandings of human diseases, and provides potential opportunities for the development of therapeutics.
Journal ArticleDOI
Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family.
Hanzhong Li,Jian Chen,Arthur J Huang,Jeremy Stinson,Sherry Heldens,Jessica Foster,Patrick Dowd,Austin L. Gurney,William I. Wood +8 more
TL;DR: There is a family of IL-17-related cytokines differing in patterns of expression and proinflammatory responses that may be transduced through a cognate set of cell surface receptors, a finding consistent with the pleiotropic activities ofIL-17.