D
David Eisenberg
Researcher at Technion – Israel Institute of Technology
Publications - 719
Citations - 120468
David Eisenberg is an academic researcher from Technion – Israel Institute of Technology. The author has contributed to research in topics: Amyloid & Protein structure. The author has an hindex of 156, co-authored 697 publications receiving 112460 citations. Previous affiliations of David Eisenberg include Howard Hughes Medical Institute & Hebrew University of Jerusalem.
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Journal ArticleDOI
Structure-based inhibitors of tau aggregation
Paul M. Seidler,David R. Boyer,David R. Boyer,Jose A. Rodriguez,Jose A. Rodriguez,Michael R. Sawaya,Michael R. Sawaya,Duilio Cascio,Duilio Cascio,Kevin A. Murray,Kevin A. Murray,Tamir Gonen,David Eisenberg,David Eisenberg +13 more
TL;DR: Atomic structures of the aggregation-prone segment VQIINK in repeat 2 of tau have been reported, and inhibitors designed using these structures block seeding by full-length tau better than inhibitors that target the VQIVYK aggregation segment in repeat 3.
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The discovery of the! -helix and" -sheet, the principal structural features of proteins
TL;DR: The α-helix and the β-sheet were proposed by Linus Pauling, Robert Corey, and Herman Branson in the spring of 1951 as mentioned in this paper, and they deduced these fundamental building blocks from properties of small molecules known both from crystal structures and from Pauling's resonance theory of chemical bonding that predicted planar peptide groups.
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Use of mind-body medical therapies.
TL;DR: Analysis of a large nationally representative dataset that comprehensively evaluated the use of mind-body therapies in the last year found that 18.9% of adults had used at least 1 mind- body therapy in theLast year, and meditation, imagery, and yoga were the most commonly used techniques.
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A specific secretion system mediates PPE41 transport in pathogenic mycobacteria.
Abdallah M. Abdallah,Theo Verboom,Fredericke Hannes,Mohamad Safi,Michael J. Strong,David Eisenberg,René J. P. Musters,Christina M. J. E. Vandenbroucke-Grauls,Ben J. Appelmelk,Joen Luirink,Wilbert Bitter +10 more
TL;DR: One of the PPE proteins, i.e. PPE 41, is secreted by pathogenic mycobacteria, both in culture and in infected macrophages, as PPE41 lacks a signal sequence, and a dedicated secretion system must be involved.
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Finding families for genomic ORFans.
Daniel Fischer,David Eisenberg +1 more
TL;DR: This commentary refers to these orphan ORFs as ‘ORFans’ and asks why there are so many, and how they can be assigned to known protein families.