D
David Eisenberg
Researcher at Technion – Israel Institute of Technology
Publications - 719
Citations - 120468
David Eisenberg is an academic researcher from Technion – Israel Institute of Technology. The author has contributed to research in topics: Amyloid & Protein structure. The author has an hindex of 156, co-authored 697 publications receiving 112460 citations. Previous affiliations of David Eisenberg include Howard Hughes Medical Institute & Hebrew University of Jerusalem.
Papers
More filters
Journal ArticleDOI
Identifying the amylome, proteins capable of forming amyloid-like fibrils
TL;DR: The amylome is the universe of proteins that are capable of forming amyloid-like fibrils and the presence in the protein of a segment that can form a tightly complementary interface with an identical segment permits the formation of a steric zipper.
Journal ArticleDOI
The primary mechanism of attenuation of bacillus Calmette–Guérin is a loss of secreted lytic function required for invasion of lung interstitial tissue
Tsungda Hsu,Suzanne M. Hingley-Wilson,Bing Chen,Mei Chen,Annie Z. Dai,Paul M. Morin,Carolyn Marks,Jeevan Padiyar,Celia W. Goulding,Mari Gingery,David Eisenberg,Robert G. Russell,Steven C. Derrick,Frank M. Collins,Sheldon L. Morris,C. Harold King,William R. Jacobs +16 more
TL;DR: The primary attenuating mechanism of bacillus Calmette–Guérin is the loss of cytolytic activity mediated by secreted ESAT-6, which results in reduced tissue invasiveness.
Journal ArticleDOI
3D domain swapping: As domains continue to swap
Yanshun Liu,David Eisenberg +1 more
TL;DR: It is suggested that 3D domain swapping can occur under appropriate conditions in any protein with an unconstrained terminus and that the swapped domains are diverse in their primary and secondary structures.
Journal ArticleDOI
The HUPO PSI's molecular interaction format--a community standard for the representation of protein interaction data.
Henning Hermjakob,Luisa Montecchi-Palazzi,Gary D. Bader,Jérôme Wojcik,Lukasz Salwinski,Arnaud Ceol,Susan Moore,Sandra Orchard,Ugis Sarkans,Christian von Mering,Bernd Roechert,Sylvain Poux,Eva Jung,Henning Mersch,Paul J. Kersey,Michael Lappe,Yixue Li,Rong Zeng,Debashis Rana,Macha Nikolski,Holger Husi,Christine Brun,K. Shanker,Seth G. N. Grant,Chris Sander,Peer Bork,Weimin Zhu,Akhilesh Pandey,Alvis Brazma,Bernard Jacq,Marc Vidal,David James Sherman,Pierre Legrain,Gianni Cesareni,Ioannis Xenarios,David Eisenberg,Boris Steipe,Christopher W. V. Hogue,Rolf Apweiler +38 more
TL;DR: This work proposes a community standard data model for the representation and exchange of protein interaction data, jointly developed by members of the Proteomics Standards Initiative (PSI) and the Human Proteome Organization (HUPO).
Journal ArticleDOI
The crystal structure of diphtheria toxin
Seunghyon Choe,Melanie J. Bennett,Gary Fujii,Paul M. G. Curmi,Katherine A. Kantardjieff,R. John Collier,David Eisenberg +6 more
TL;DR: The crystal structure of the diphtheria toxin dimer at 2.5 Å resolution reveals a Y-shaped molecule of three domains that can be useful in designing chimaeric proteins, such as immunotoxins, in which the receptor-binding domain is substituted with antibodies to target other cell types.