David Eisenberg

TL;DR: This study developed an approach that combines the structure-based rational design with chemical modification for the development of amyloid inhibitors, which could be applied to the developed of therapeutics for different amyloids-related diseases.

TL;DR: This work reports the 1.0 Å resolution micro-electron diffraction structure of an aggregation-prone segment of tau with the sequence SVQIVY, present in the cores of patient-derived fibrils from AD and tauopathies, and shows that tau-capping inhibitors can be transiently expressed in HEK293 tau biosensor cells, indicating that nucleic acid–based vectors can be used for inhibitor delivery.

TL;DR: Hospitals are using heterogeneous approaches to address licensure, credentialing, scope of practice, malpractice liability, and dietary supplement use in developing models of integrative care.

TL;DR: Studies of mutant and oxidized enzymes confirm that there are at least two stages of oxidative modification of GS, and suggest that the early modification occurs at the n2 metal ion site, eliminating enzyme activity, and the later modification occursat the n1 metal ions site, relaxing the GS structure, perhaps enabling proteolytic degradation.

TL;DR: This manuscript summarizes the rationale, methods and preliminary "proof of principle" for the establishment of this prototype, authenticated medicinal plant library and it is hoped that these methods will foster scientific discoveries with therapeutic potential and enhance efforts to systematically evaluate commonly used herbal therapies worldwide.