David H. Burns

TL;DR: Rapid, noninvasive metabolomic profiling of human embryo culture media using Raman or near-infrared spectroscopy combined with bioinformatics correlates with pregnancy outcome.

TL;DR: There is a clear relationship between the reproductive potential of human embryos and their modification of their culture media as detected by Raman biospectroscopy-based metabolomic profiling.

TL;DR: In patients with highly stenoticCarotid lesions who are undergoing carotid endarterectomy, gross plaque composition is similar regardless of preoperative symptom status, and it is unlikely that differences in the volume of intraplaque hemorrhage, lipid core, necrotic core, or calcification in atheroscleroticcarotid plaques explain their embolic history.

TL;DR: Glutamate concentrations determined by (1)H NMR were significantly higher in spent culture media of embryos that resulted in pregnancy and delivery compared to those that failed to implant.

TL;DR: NIR metabolomic profiling of spent embryo culture media was able to distinguish viable embryos from non-viable embryos for reproduction and produced unique metabolomic profiles that correlated to an embryo's reproductive potential.