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David J. Flint
Researcher at Strathclyde Institute of Pharmacy and Biomedical Sciences
Publications - 124
Citations - 5503
David J. Flint is an academic researcher from Strathclyde Institute of Pharmacy and Biomedical Sciences. The author has contributed to research in topics: Mammary gland & Adipose tissue. The author has an hindex of 38, co-authored 123 publications receiving 5156 citations. Previous affiliations of David J. Flint include University of Strathclyde.
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Journal ArticleDOI
Gold Nanoparticles for the Improved Anticancer Drug Delivery of the Active Component of Oxaliplatin
Sarah Brown,Paola Nativo,Jo-Ann Smith,David Stirling,Paul R. Edwards,Balaji Venugopal,David J. Flint,Jane A. Plumb,Duncan Graham,Nial J. Wheate +9 more
TL;DR: In this paper, the active component of the cancer drug oxaliplatin was tethered to a gold nanoparticle for improved drug delivery and the platinum-tethered nanoparticles were examined for cytotoxicity, drug uptake, and localization in the A549 lung epithelial cancer cell line and the colon cancer cell lines HCT116, HCT15, HT29, and RKO.
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Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3
Rachel S. Chapman,Paula C. C. Lourenço,Elizabeth Tonner,David J. Flint,Stefan Selbert,Kiyoshi Takeda,Shizuo Akira,Alan Richard Clarke,Christine J. Watson +8 more
TL;DR: It is suggested that IGFBP-5 is a direct or indirect target for Stat3 and its upregulation is essential to normal involution, and the importance of a Stat factor in signaling the initiation of physiological apoptosis in vivo is demonstrated.
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Insulin-like growth factor-binding protein-5 (IGFBP-5): a critical member of the IGF axis
TL;DR: The regulation of IGFBP-5 expression is examined and its potential role in tumour biology is commented on, with special reference to work with breast cancer cells.
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Control of Milk Secretion and Apoptosis DuringMammary Involution
TL;DR: Local control of apoptosis in rodents during weaning, and after peak lactation in dairyanimals, may be due to the actions of milk-bornesurvival factors or their inhibitors, and can bemanipulated by frequency of milk removal.
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Hormonal control of insulin-like growth factor-binding protein-5 production in the involuting mammary gland of the rat.
TL;DR: IGBP-5 may, in fact, play a central role in inducing apoptosis, as it is also up-regulated in involuting prostate and thyroid glands as well as in atretic ovarian follicles.